Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott +12 more
wiley +1 more source
Hepatology Communications, 2018 Prohibitin1 (PHB1) is a mitochondrial chaperone with diverse functions that include cell proliferation, apoptosis, and mitochondrial homoeostasis. Liver‐specific Phb1 knockout (KO) mice develop spontaneous injury and hepatocellular carcinoma (HCC).
Nirmala Mavila +6 more
doaj +1 more source
Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]
, 2015 Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X +4 more
core +3 more sources
Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond
Advanced Science, Volume 12, Issue 44, November 27, 2025.Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao +7 more
wiley +1 more source
Role of WNT16 in the Regulation of Periosteal Bone Formation in Female Mice [PDF]
Endocrinology, 2015 In this study, we evaluated the role of WNT16 in regulating bone size, an important determinant of bone strength. Mice with targeted disruption of the Wnt16 gene exhibited a 24% reduction in tibia cross-sectional area at 12 weeks of age compared with that of littermate wild-type (WT) mice.
Jon E, Wergedal +4 more
openaire +2 more sources
WNT signalling in prostate cancer [PDF]
, 2017 Genome sequencing and gene expression analyses of prostate tumours have highlighted the potential importance of genetic and epigenetic changes observed in WNT signalling pathway components in prostate tumours-particularly in the development of castration-
A Ghoshal +166 more
core +2 more sources
A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures [PDF]
BoneKEy Reports, 2015 The last decade has provided abundant data implicating the WNT pathway in bone development and in the regulation of skeletal homeostasis. Rare human mutations together with gain- and loss-of-function approaches in mice have clearly demonstrated that disrupted regulation of this pathway leads to altered bone mass.
Francesca, Gori +3 more
openaire +2 more sources
Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts [PDF]
, 2016 published_or_final_versio
Bai, J +24 more
core +1 more source
The bone-sparing effects of estrogen and WNT16 are independent of each other [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance Previous studies demonstrate that endogenous wingless-type MMTV integration site family (WNT)16 is a crucial regulator of cortical bone mass. Surprisingly, we demonstrate that overexpression of WNT16 increases mainly trabecular bone mass.
Moverare-Skrtic S +14 more
openaire +3 more sources
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]
, 2018 Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar +66 more
core +3 more sources