Results 101 to 110 of about 4,011 (186)
Aging Cell, Volume 24, Issue 10, October 2025.The chromatin accessibility landscape of senescent cells is remodeled, with a set of activated transcription factors physically binding to the enhancers and promoters of senescence‐associated genes, including those encoding SASP factors. Events such as epigenomic reprogramming and KDM4‐mediated histone demethylation (H3K9/H3K36) enable SASP expression ...
Boyi Zhang +17 more
wiley +1 more source
MULTIFACTORIAL PATHOGENESIS OF OSTEOPOROSIS AND THE ROLE OF GENES OF CANONICAL WNT-SIGNALING PATHWAY
Остеопороз и остеопатии, 2015 Nowadays, multifactorial nature of osteoporosis does not raise any doubts. Besides, it should be noted that about 90% disease cases are determined genetically.
E A Mailyan
doaj +1 more source
International Journal of Cancer, Volume 157, Issue 3, Page 559-572, 1 August 2025.What's new? Too often, children treated for B‐cell acute lymphocytic leukemia (B‐ALL) experience relapse. Here, the authors investigate the role of dyslipidemia in leukemia progression. Higher adipogenicity in bone marrow mesenchymal stem cells, and increased triglyceride accumulation, are associated with higher risk of death.
Lili Song +10 more
wiley +1 more source
Genome-wide assessment of differential effector gene use in embryogenesis [PDF]
, 2015 Six different populations of cells were isolated by FACS from disaggregated late blastula and gastrula stage sea urchin embryos according to the regulatory states expressed in these cells, as reported by recombineered BACs producing fluorochromes ...
Barsi, Julius C. +3 more
core +2 more sources
Osteoarthritis: Mechanisms and Therapeutic Advances
MedComm, Volume 6, Issue 8, August 2025.A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu +3 more
wiley +1 more source
GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish [PDF]
, 2015 Glucose transporter 2 (GLUT2; gene name SLC2A2) has a key role in the regulation of glucose dynamics in organs central to metabolism. Although GLUT2 has been studied in the context of its participation in peripheral and central glucose sensing, its role ...
Crespo Morao, Diego +5 more
core +2 more sources
Genetics and Vitamin D Interactions in Osteoporosis: A Path to Precision Medicine
Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.ABSTRACT Osteoporosis is a systemic skeletal disease characterized by reduced bone mineral density (BMD) and increased fracture risk; it poses a significant global health challenge. The multifactorial pathogenesis of osteoporosis involves complex interactions between genetic factors and vitamin D metabolism, particularly involving key genes such as the
Sepideh Abdollahi +5 more
wiley +1 more source
Wnt16 regulates chondrocyte differentiation through Wnt/ planar cell polarity (PCP) pathway
The FASEB Journal, 2018 Wnt signaling, a highly conserved signaling pathway, plays important roles in endochondral ossification which is a key process for skeletal development and bone repair. Wnt16, as one of the nineteen Wnt ligands, is reported to repress osteoclastogenesis, prevent cortical bone fragility fractures and to be upregulated in ...
Yelin ZENG +3 more
openaire +1 more source
The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes [PDF]
, 2015 Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in osteoarthritis (OA).
Huang, X. +3 more
core +2 more sources
Comparative transcriptomics enlarges the toolkit of known developmental genes in mollusks [PDF]
, 2016 Data used for the phylogenetic analysis of Hox and ParaHox genes, including the respective GenBank accession numbers.
A. Kristof +7 more
core +2 more sources