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Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk. [PDF]
J Transl MedZhou Y +10 more
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Genetic and metabolic mechanisms underlying webbed feet pigmentation in geese: Insights from histological, transcriptomic, and metabolomic analyses. [PDF]
Poult SciLiu Y +5 more
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A review on anti-cancer properties of quercetin in gastric cancer. [PDF]
Front PharmacolXie X, Wei Y.
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Comparative genomics on Wnt16 orthologs
Oncology Reports, 2005The WNT16 gene at human chromosome 7q31.31 encodes two isoforms due to alternative splicing of an alternative promoter type. Here, we identified and characterized the rat Wnt16 and zebrafish wnt16 genes using bioinformatics. The rat Wnt16 and zebrafish wnt16 genes, consisting of four exons, were located within the AC117014.4 and CR925699.1 genome ...
Yuriko, Katoh, Masaru, Katoh
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Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a
Biochemical and Biophysical Research Communications, 2015The canonical Wnt/β-catenin signaling pathway in osteoblast-lineage cells inhibits osteoclastogenesis through the expression of osteoprotegerin (Opg), a decoy receptor of receptor activator of Nf-κb (Rank) ligands. Wnt5a, a typical non-canonical Wnt ligand, enhances the expression of Rank in osteoclast precursors, which, in turn, promotes the Rank ...
Yasuhiro Kobayashi +8 more
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Wnt16 attenuates osteoarthritis progression through a PCP/JNK-mTORC1-PTHrP cascade
Annals of the Rheumatic Diseases, 2019Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional relationship in OA progression in chondrocyte ...
Wenxue Tong +11 more
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Multiple Mechanisms Explain Genetic Effects at the CPED1-WNT16 Bone Mineral Density Locus
Current Osteoporosis Reports, 2023Chromosome region 7q31.31, also known as the CPED1-WNT16 locus, is robustly associated with BMD and fracture risk. The aim of the review is to highlight experimental studies examining the function of genes at the CPED1-WNT16 locus.Genes that reside at the CPED1-WNT16 locus include WNT16, FAM3C, ING3, CPED1, and TSPAN12.
Arianna Ericka Gómez +10 more
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Regulatory Fluctuation of WNT16 Gene Expression Is Associated with Human Gastric Adenocarcinoma
Journal of Gastrointestinal Cancer, 2017Gastric cancer is one of the most serious and lethal kinds of cancer in the world. It is a multi-step, multi-factor, and elaborated process that is associated to gene abnormal expression. This study intended to investigate the WNT16 gene's expression in human gastric tumor and the margin tissues of the stomach (normal tissues).Correspondingly, 40 ...
Seyedeh Elham, Norollahi +4 more
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