Results 11 to 20 of about 4,011 (186)
Wnt16 signaling in bone homeostasis and osteoarthristis
Frontiers in Endocrinology, 2022 Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal homeostasis and have been implicated in the occurrence of osteoarthritis.
Xiaoping Ye, Xianwen Liu
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WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis [PDF]
Arthritis Research & Therapy, 2021 Background WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of AS in an in vitro model.
Sungsin Jo +7 more
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WNT16 Regulation of the Articular Chondrocyte Phenotype in Mice
Life, 2023 The anabolic effects of WNT16 on osteoblasts are well established, however, little is known regarding the role of WNT16 in chondrocytes. In this study, we evaluated Wnt16 expression and its biological effects on mouse articular chondrocytes (ACs), since ...
Subburaman Mohan +2 more
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wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome. [PDF]
PLoS Genetics, 2022 Bone and muscle are coupled through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits.
Claire J Watson +20 more
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Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo [PDF]
Scientific Reports, 2018 Glucocorticoid-induced osteoporosis is a frequent complication of systemic glucocorticoid (GC) therapy and mainly characterized by suppressed osteoblast activity. Wnt16 derived from osteogenic cells is a key determinant of bone mass.
Baschant, Ulrike +5 more
core +4 more sources
Potential Interaction between WNT16 and Vitamin D on Bone Qualities in Adolescent Idiopathic Scoliosis Patients and Healthy Controls [PDF]
BiomedicinesAdolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity that is associated with low bone mineral density (BMD). Vitamin D (Vit-D) supplementation has been suggested to improve BMD in AIS, and its outcomes may be related to genetic ...
Guangpu (Kenneth) Yang +8 more
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PLoS Genetics, 2012 We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and ...
Hou-Feng Zheng +54 more
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A transcriptomic analysis of dental pulp stem cell senescence in vitro [PDF]
BioMedical Engineering OnLineBackground/purpose The use of human dental pulp stem cells (hDPSCs) as autologous stem cells for tissue repair and regenerative techniques is a significant area of global research.
Jidong Xu +5 more
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Quantification of Wnt3a, Wnt5a and Wnt16 Binding to Multiple Frizzleds Under Physiological Conditions Using NanoBit/BRET [PDF]
CellsUpon engagement of one of the nineteen secreted Wnt signaling proteins with one of the ten Frizzled transmembrane Wnt receptors (FZD1–10), a wide variety of cellular Wnt signaling responses can be elicited, the selectivity of which depends on the ...
Janine Wesslowski +4 more
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Ecology and EvolutionNotoptera, as a unique ancient insect lineage, elucidates the linkage between insect biodiversity and geological history. Members of this order are recognized as National First‐Class Protected Animals in China.
Yanhan Zhou +9 more
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