Results 21 to 30 of about 4,011 (186)
Associations Between Body Mass Index, WNT16 rs2908004 and Osteoporosis: Findings from Taiwan Biobank
Journal of Multidisciplinary Healthcare, 2022 Chi-Ling Wu,1 Oswald Ndi Nfor,1 Disline Manli Tantoh,1,2 Wen-Yu Lu,1 Yung-Po Liaw1– 3 1Department of Public Health, Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan; 2Department of Medical Imaging, Chung Shan Medical ...
Wu CL +4 more
doaj +3 more sources
Introducing Wnt16 attenuates the severity of osteoarthritis
Journal of Orthopaedic Translation, 2016 Wenxue Tong +2 more
doaj +2 more sources
A somitic Wnt16/Notch pathway specifies haematopoietic stem cells [PDF]
Nature, 2011 Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously replenish all blood and immune cells during the lifetime of an individual. HSCs are used clinically to treat a wide array of diseases, including acute leukaemias and congenital blood disorders, but obtaining suitable numbers of cells and finding immune-compatible
Wilson K, Clements +5 more
openaire +3 more sources
Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice [PDF]
Journal of Endocrinology, 2018 Substantial progress has been made in the therapeutic reduction of vertebral fracture risk in patients with osteoporosis, but non-vertebral fracture risk has been improved only marginally. Human genetic studies demonstrate that the WNT16 locus is a major determinant of cortical bone thickness and non-vertebral fracture risk and mouse models with life ...
Ohlsson, C. (Claes) +13 more
openaire +3 more sources
La variante missense rs2908004 de WNT16 actúa como eQTL de FAM3C en osteoblastos primarios humanos
Revista de Osteoporosis y Metabolismo Mineral, 2021 Introducción: WNT16 es un gen importante en la homeostasis ósea, que se encuentra en un locus muy complejo que también incluye los genes vecinos: ING3, FAM3C y CPED1. Además del claro papel de WNT16 sobre la determinación de la densidad mineral ósea (DMO)
Martínez-Gil N +4 more
doaj +1 more source
Age‐related bone associated comorbidity indicated as changes in the plasma bone and senescence markers in Alzheimer's disease patients [PDF]
Alzheimers DementAbstract Background Dementia represents a significant health and societal challenge, identified as a primary cause of mortality worldwide and closely associated with the aging population. A 24‐year follow up study indicated that socioeconomic status affects the risk of multimorbidity including dementia, frailty, and disability, with multimorbidity ...
Kaipa S +11 more
europepmc +2 more sources
WNT16 overexpression partly protects against glucocorticoid-induced bone loss [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2018 Therapeutic use of glucocorticoids (GCs) is a major cause of secondary osteoporosis, but the molecular mechanisms responsible for the deleterious effects of GCs in bone are only partially understood. WNT16 is a crucial physiological regulator of bone mass and fracture susceptibility, and we hypothesize that disturbed WNT16 activity might be involved ...
Claes Ohlsson +7 more
openaire +3 more sources
Bioactive Materials, 2023 Implant failure, which is commonly associated with failure of osseointegration and peri-implant infection, is a severe complication of orthopedic surgery. In particular, the survival rate of implants is significantly decreased in patients using long-term
Zhe Liu +7 more
doaj +1 more source
Wnt16 Attenuates TGFβ-Induced Chondrogenic Transformation in Vascular Smooth Muscle [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Objective— Phenotypic plasticity of vascular smooth muscle cells (VSMCs) contributes to cardiovascular disease. Chondrocyte-like transformation of VSMCs associates with vascular calcification and underlies the formation of aortic cartilaginous metaplasia induced in mice by genetic loss of matrix Gla protein (MGP).
Kelly E, Beazley +4 more
openaire +2 more sources