Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures [PDF]
Nature Medicine, 2014 The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity ...
Sofia Movérare-Skrtic +30 more
openaire +2 more sources
Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment [PDF]
, 2014 Heritability of bone mineral density (BMD) varies across skeletal sites, reflecting different relative contributions of genetic and environmental influences.
Ackert-Bicknell, C.L. (Cheryl) +32 more
core +1 more source
Progeria and Aging—Omics Based Comparative Analysis
Biomedicines, 2022 Since ancient times aging has also been regarded as a disease, and humankind has always strived to extend the natural lifespan. Analyzing the genes involved in aging and disease allows for finding important indicators and biological markers for ...
Aylin Caliskan +4 more
doaj +1 more source
Specific functions of the Wnt signaling system in gene regulatory networks throughout the early sea urchin embryo [PDF]
, 2014 Wnt signaling affects cell-fate specification processes throughout embryonic development. Here we take advantage of the well-studied gene regulatory networks (GRNs) that control pregastrular sea urchin embryogenesis to reveal the gene regulatory ...
Cui, Miao +4 more
core +2 more sources
Frontiers in Endocrinology, 2022 ObjectiveTo evaluate the clinical features of sporadic Paget’s disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease.MethodsClinical characteristics, biochemical indices, bone turnover markers and ...
Xiaohui Tao +7 more
doaj +1 more source
Wnt5a Signaling in Normal and Cancer Stem Cells. [PDF]
, 2017 Wnt5a is involved in activating several noncanonical Wnt signaling pathways, which can inhibit or activate canonical Wnt/β-catenin signaling pathway in a receptor context-dependent manner.
Kipps, Thomas J +2 more
core +2 more sources
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish [PDF]
, 2012 Multiple signaling pathways control the specification of endothelial cells (ECs) to become arteries or veins during vertebrate embryogenesis. Current models propose that a cascade of Hedgehog (Hh), vascular endothelial growth factor (VEGF), and Notch ...
Bahary +58 more
core +2 more sources
Differential expression of WNT16 in pancreatic cancer.
, 2023 Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined public and published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma ...
openaire +1 more source
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes [PDF]
Rheumatology International, 2017 Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA phenotype. We studied 509 Caucasian patients undergoing joint replacement due to severe primary OA.
García Ibarbia, María del Carmen +7 more
openaire +3 more sources
Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: Targeting new genes in regeneration [PDF]
, 2013 Tissue regeneration is a complex trait with few genetic models available. Mouse strains LG/J and MRL are exceptional healers. Using recombinant inbred strains from a large (LG/J, healer) and small (SM/J, nonhealer) intercross, we have previously shown a ...
Cheverud, James M +4 more
core +2 more sources