Results 51 to 60 of about 4,011 (186)
Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]
, 2019 Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina +7 more
core +3 more sources
Stem Cell Research, 2018 The skin constantly self-renews throughout adult life. Wnt/β-catenin signaling plays a key role in promoting keratinocyte proliferation in the hair follicles and in the interfollicular epidermis.
Veronica Mendoza-Reinoso +1 more
doaj +1 more source
Altered Expression of PRKX, WNT3 and WNT16 in Human Nodular Basal Cell Carcinoma [PDF]
Anticancer Research, 2016 Nodular and superficial are the most common subtypes of basal cell carcinoma (BCC). Signaling pathways such as Hedgehog (HH) and Wingless (WNT) signaling are associated with BCC phenotypic variation. The aim of the study was to evaluate of the expression profiles of 84 genes related to the WNT and HH signaling pathways in patients with nodular and ...
Natalia Gurgel, DO Carmo +6 more
openaire +2 more sources
Stem Cells International, 2019 The application of mesenchymal stem cells (MSCs) for treating bone-related diseases shows promising outcomes in preclinical studies. However, cells that are isolated and defined as MSCs comprise a heterogeneous population of progenitors.
Yu-Hee Kim +7 more
doaj +1 more source
Proteomic characterization of thiazolidinedione regulation of obese adipose secretome in Zucker obese rats [PDF]
, 2009 Signaling molecules released by adipose tissue have been implicated in inflammation, adipocyte dysfunction and systemic insulin resistance. In this study, we used 2-D LC-MS/MS and quantitative proteomics approaches to characterize the obese adipose ...
Chen, Xiaoli +3 more
core +1 more source
New Insights into Wnt-Lrp5/6-β-Catenin Signaling in Mechanotransduction [PDF]
, 2015 Mechanical loading is essential to maintain normal bone metabolism and the balance between bone formation and resorption. The cellular mechanisms that control mechanotransduction are not fully defined, but several key pathways have been identified.
Kang, Kyung Shin, Robling, Alexander G.
core +3 more sources
Osteoblast-Osteoclast Communication and Bone Homeostasis
Cells, 2020 Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim +4 more
doaj +1 more source
Multi-label multi-instance transfer learning for simultaneous reconstruction and cross-talk modeling of multiple human signaling pathways [PDF]
, 2015 Text file contains the predicted cross-talk signaling components between human signaling pathways (homolog instance).
Hao Zhu, Suyu Mei
core +12 more sources
Journal of Prosthodontics, EarlyView.Abstract Purpose Few studies have explored the bone response in dental implant sites prepared using a piezoelectric device, indicating moderate effectiveness in enhancing secondary stability and osteogenesis. This study seeks to expand our understanding of the changes in biological, clinical, and radiographic parameters, during the initial phases of ...
Gianmario Schierano +8 more
wiley +1 more source
PLoS Genetics, 2012 To identify genetic loci influencing bone accrual, we performed a genome-wide association scan for total-body bone mineral density (TB-BMD) variation in 2,660 children of different ethnicities.
Carolina Medina-Gomez +27 more
doaj +1 more source