Results 71 to 80 of about 4,011 (186)

Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2 [PDF]

, 2013
BACKGROUND: The discovery of TCF7L2 as a global type 2 diabetes (T2D) gene has sparked investigations to explore the clinical utility of its variants for guiding the development of new diagnostic and therapeutic strategies.
Daniel Brackett, Dharambir K Sanghera, Elizabeth C Bullen, Eric W Howard, Latonya F Been, Megan Lerner, Stan Lightfoot   +6 more
core   +1 more source

TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
1. TIMP2 is upregulated in injured renal tubules and promotes maladaptive repair and cell senescence. 2. Genetic deletion of TIMP2 in tubular epithelial cells attenuates renal fibrosis and improves mitochondrial function. 3. TIMP2 activates Wnt/β‐catenin signalling by binding to LRP6 via an MMP‐independent mechanism.
Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng   +6 more
wiley   +1 more source

Differential expression of WNT16 in amyotrophic lateral sclerosis.

, 2022
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression ...
openaire   +1 more source

Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells

Scientific Reports, 2022
Osteoblast differentiation requires the interaction of various cell signaling pathways to modulate cell responses. Notch and Wnt signaling are among the crucial pathways that control numerous biological processes, including osteo/odontogenic ...
Chatvadee Kornsuthisopon, Ajjima Chansaenroj, Jeeranan Manokawinchoke, Kevin A. Tompkins, Nopadon Pirarat, Thanaphum Osathanon   +5 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice

Discover Oncology, 2023
Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated.
Wanting Xue, Lihong Cai, Su Li, Yujia Hou, Yan-Dong Wang, Dongbin Yang, Yubing Xia, Xiaobo Nie   +7 more
doaj   +1 more source

Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome [PDF]

, 2018
Background: Genetic classification of breast cancer based on the coding mRNA suggests the evolution of distinct subtypes. Whether the non-coding genome is altered concordantly with the coding genome and the mechanism by which the cell cycle directly ...
Addya, Sankar, Casimiro, Mathew C., Deng, Shengqiong, DiSante, Gabriele, Dong, Lin, Ertel, Adam, Gormley, Michael, Ju, Xiaoming, Li, Qinchuan, Pestell, Richard G., Pestell, Timothy G., Qiao, Jing, Tozeren, Ayden, Wang, Guangxue, Wang, Min, Yu, Zuoren, Zhao, Qian   +16 more
core   +2 more sources

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]

, 2014
The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core   +3 more sources

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

MedComm, Volume 7, Issue 1, January 2026.
The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin, Jiahui Wang, Runyi Cao, Dongsheng Jiang   +3 more
wiley   +1 more source