Results 211 to 220 of about 270,248 (329)

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/β-catenin-regulated cell proliferation

, 2002
Guangnan Li, Ravi Iyengar
openalex   +1 more source

Altered Expression of Genes of the Bmp/Smad and Wnt/Calcium Signaling Pathways in the Cone-only Nrl-/- Mouse Retina, Revealed by Gene Profiling Using Custom cDNA Microarrays [PDF]

, 2004
Jindan Yu, Shirley He, James S. Friedman, Masayuki Akimoto, Debashis Ghosh, Alan J. Mears, David Hicks, Anand Swaroop   +7 more
openalex   +1 more source

Noncanonical WNT signaling pathways in C. Elegans converge on POP-1/TCF and control cell polarity [PDF]

, 2004
M.A. Herman
openalex   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

Advanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding   +9 more
wiley   +1 more source

Identification of the Oncogenic Role of MSH2 in the Stemness and Progression of Glioma Through Regulating Wnt Signaling Pathway. [PDF]

Cancer Med
Liu J, Chen J, Jiang L.
europepmc   +1 more source

Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis [PDF]

, 2004
Sergio Ruiz, Carmen Segrelles, Mirentxu Santos, M. Fernanda Lara, Jesús M. Paramio   +4 more
openalex   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

NRF2 modulates WNT signaling pathway to enhance photodynamic therapy resistance in oral leukoplakia. [PDF]

EMBO Mol Med
Xu T, Zhong L, Liu Q, Wang F, Kuang W, Liang J, Yang D, Zhou X, Dan H, Zhao H, Li T, Zeng X, Li J, Chen Q.   +13 more
europepmc   +1 more source

Multiple Mechanisms for Wnt11-mediated Repression of the Canonical Wnt Signaling Pathway [PDF]

, 2004
Peter Maye, Jie Zheng, Lin Li, Dianqing Wu   +3 more
openalex   +1 more source