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Wnt signalling pathway in bladder cancer
Cellular Signalling, 2021Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new ...
Guanlin, Wu +7 more
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Wnt signaling pathway: A comprehensive review
Cell Biology International, 2022AbstractWnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical for a variety of physiological processes of an organism's body, including stem cell regeneration, proliferation, division, migration, polarity of a cell, determining fate of the cell and specification of neural crest, neural symmetry and morphogenesis.
Rabia Hayat +2 more
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Wnt signaling pathway in cancer immunotherapy
Cancer Letters, 2022Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation, differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing. Dysregulation of the Wnt pathway is intricately involved in almost all stages of tumorigenesis in various cancers. Through direct and/or indirect effects on effector T cells,
Yang Zhou +5 more
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Wnt signalling: pathway or network?
Current Opinion in Genetics & Development, 1999Members of the Wnt family of secreted glycoproteins participate in many signalling events during development. Recent findings suggest that Wnt signals can sometimes play a permissive role during cell-fate assignment. Wnt proteins have been shown to interact with a number of extracellular and cell-surface proteins, whereas many intracellular components ...
Arias, Alfonso Martinez +2 more
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Wnt Signaling Pathway in Schizophrenia
CNS & Neurological Disorders - Drug Targets, 2014The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better ...
Yanmin, Peng, Yifeng, Xu, Donghong, Cui
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Wnt signaling pathway and lung disease
Translational Research, 2008The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility.
Michelle, Van Scoyk +5 more
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2008
Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Abstract The Wnt (wingless) signaling pathway is an important signal transduction pathway that is well conserved across animal phyla. Wnts are a large family of secreted signaling molecules known to play important and diverse roles in developmental processes such as cell fate speci7cation, cell migration, and cell proliferation ...
Lorna S Kategaya +2 more
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Wnt signaling: Sox Enters the Wnt Pathway
Science's STKE, 1999The Wnt signaling pathway regulates numerous cellular responses including those that govern axis formation and dorsal-ventral patterning in the developing Xenopus laevis embryo. Upon binding to its receptor Frizzled, a signaling cascade is triggered that results in β-catenin-dependent transcription of Wnt target ...
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Selective activation mechanisms of Wnt signaling pathways
Trends in Cell Biology, 2009Wnts comprise a large family of secreted, hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms, including cellular proliferation, differentiation, migration and polarity. Wnts have many receptors that are present on a variety of cell types, partly specifying which Wnt pathways are activated ...
Akira, Kikuchi +2 more
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The Wnt/Frizzled GPCR signaling pathway
Biochemistry (Moscow), 2010G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades are repeatedly used during animal development and are mostly silent in the adult. Improper
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