Results 311 to 320 of about 270,248 (329)
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Wnt signalling: pathway or network?
Current Opinion in Genetics & Development, 1999Members of the Wnt family of secreted glycoproteins participate in many signalling events during development. Recent findings suggest that Wnt signals can sometimes play a permissive role during cell-fate assignment. Wnt proteins have been shown to interact with a number of extracellular and cell-surface proteins, whereas many intracellular components ...
Arias, Alfonso Martinez +2 more
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Wnt signalling pathway in bladder cancer
Cellular Signalling, 2021Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new ...
Yu Xie +13 more
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Wnt Signaling Pathway in Schizophrenia
CNS & Neurological Disorders - Drug Targets, 2014The Wnt signaling pathway is one of the crucial signaling pathways that regulate many aspects of central nervous system. In this review, we tempt to depict an overall picture of the Wnt signaling with its multitude of roles in schizophrenia. If the Wnt signaling pathway plays a crucial role in the pathogenesis of schizophrenia as we suggest, a better ...
Yifeng Xu, Yanmin Peng, Donghong Cui
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Wnt signaling pathway in cancer immunotherapy
Cancer Letters, 2022Wnt/β-catenin signaling is a highly conserved pathway that regulates cell proliferation, differentiation, apoptosis, stem cell self-renewal, tissue homeostasis, and wound healing. Dysregulation of the Wnt pathway is intricately involved in almost all stages of tumorigenesis in various cancers. Through direct and/or indirect effects on effector T cells,
Yang Zhou +5 more
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The Wnt signaling pathway and bone metabolism
Current Opinion in Rheumatology, 2007The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism.The Wnt/beta-catenin signaling pathway has been shown to play a major role in bone cell differentiation,
Mark L. Johnson, Mohamed A Kamel
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The Wnt Signal Transduction Pathway
2000Wnt signaling plays a central role in the development of many phylogenetically diverse organisms including Drosophila, Caenorhabditis elegans, Xenopus, and higher vertebrates. In addition, genetic alterations of components in the pathway are associated with tumorigenesis in mice and humans, particularly melanomas and carcinomas of the breast and colon.
Bart O. Williams, Grant D. Barish
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Wnt signaling pathway and lung disease
Translational Research, 2008The Wnt pathway plays an important role in development and in regulating adult stem cell systems. A variety of cellular processes is mediated by Wnt signaling, which includes cellular proliferation, differentiation, survival, apoptosis, and cell motility.
Amen Sergew +6 more
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Wnt signaling pathway: A comprehensive review
Cell Biology International, 2022AbstractWnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical for a variety of physiological processes of an organism's body, including stem cell regeneration, proliferation, division, migration, polarity of a cell, determining fate of the cell and specification of neural crest, neural symmetry and morphogenesis.
Rabia Hayat +2 more
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The Wnt Signaling Pathway in Bipolar Disorder
The Neuroscientist, 2002The Wnt signaling pathway is a highly conserved pathway critical for proper embryonic development. However, recent evidence suggests that this pathway and one of its key enzymes, glycogen synthase kinase 3β, may play important roles in regulating synaptic plasticity, cell survival, and circadian rhythms in the mature CNS—all of which have been ...
Todd D. Gould, Husseini K. Manji
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The Canonical Wnt Signaling Pathway in Autism
CNS & Neurological Disorders - Drug Targets, 2014Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the
Xiang-Shan Yuan +3 more
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