Results 321 to 329 of about 270,248 (329)

An arrow hits the Wnt signaling pathway

Trends in Neurosciences, 2001
A recent series of papers in Nature shows that low-density lipoprotein receptor-related protein family members play a role in transduction of Wnt signals. These findings, in addition to other work from the past two years, have important implications for the role of Wnts in neural development.
openaire   +3 more sources

The Hedgehog and Wnt signalling pathways in cancer

Nature, 2001
The Wnt and Hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal.
Jussi Taipale, Philip A. Beachy
openaire   +2 more sources

Roles of Axin in the Wnt Signalling Pathway

Cellular Signalling, 1999
The Wnt signalling pathway is conserved in various species from worms to mammals, and plays important roles in development, cellular proliferation, and differentiation. The molecular mechanisms by which the Wnt signal regulates cellular functions are becoming increasingly well understood.
openaire   +3 more sources

The Wnt/Frizzled GPCR signaling pathway

Biochemistry (Moscow), 2010
G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades are repeatedly used during animal development and are mostly silent in the adult. Improper
Vladimir L. Katanaev, Vladimir L. Katanaev   +1 more
openaire   +3 more sources

The Wnt signaling pathway and rheumatoid arthritis

Autoimmunity Reviews, 2010
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The
Francisco Aires Correa Lima, Francieli de Sousa Rabelo, Rodrigo Aires Corrêa Lima, Gustavo Barcelos Barra, Jozélio Freire de Carvalho, Licia Maria Henrique da Mota, Angélica Amorim Amato   +6 more
openaire   +3 more sources

Crosstalk of the Wnt Signaling Pathway

2010
While it is very clear that activation of β-catenin through the canonical Wnt ­pathway plays a role in a multitude of human cancers, it has also been noted time and time again that activation of β-catenin is observed in tumors without any clear mutation in any of the major components of the pathway or any increase in Wnt signaling.
Kari Nejak-Bowen, Satdarshan P.S. Monga, Michael A. Thompson   +2 more
openaire   +2 more sources

The Wnt Signaling Pathway in Retinal Degenerations

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005
The retina is a complex tissue composed of multiple interconnected cell layers, highly specialized for transforming light and color into electrical signals perceived by the brain. Damage or death of the primary light-sensing cells, the photoreceptors, results in devastating effects on vision.
openaire   +3 more sources

Craniopharyngiomas and Wnt signalling pathways

Endocrine Abstracts, 2013
Roderick J. Clifton-Bligh, Veronica Preda, Olaf Ansorge, Bruce G. Robinson, Niki Karavitaki, Sarah Larkin, Ashley Grossman   +6 more
openaire   +2 more sources

The Wnt's Tale: On the Evolution of a Signaling Pathway

2014
Croce, Jenifer, Holstein, Thomas
openaire   +1 more source