Results 321 to 330 of about 289,302 (355)
Some of the next articles are maybe not open access.
The Wnt Signaling Pathway in Bipolar Disorder
The Neuroscientist, 2002The Wnt signaling pathway is a highly conserved pathway critical for proper embryonic development. However, recent evidence suggests that this pathway and one of its key enzymes, glycogen synthase kinase 3β, may play important roles in regulating synaptic plasticity, cell survival, and circadian rhythms in the mature CNS—all of which have been ...
Todd D, Gould, Husseini K, Manji
openaire +2 more sources
The Wnt signaling pathway and bone metabolism
Current Opinion in Rheumatology, 2007The Wnt signaling pathway has been a major focus of effort in the bone field for the past 5 years. This review will examine some of the seminal findings that have brought us to our current understanding of the role of this pathway in bone metabolism.The Wnt/beta-catenin signaling pathway has been shown to play a major role in bone cell differentiation,
Mark L, Johnson, Mohamed A, Kamel
openaire +2 more sources
The Canonical Wnt Signaling Pathway in Autism
CNS & Neurological Disorders - Drug Targets, 2014Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the
Yinghua, Zhang +3 more
openaire +2 more sources
The Wnt Signal Transduction Pathway
2000Wnt signaling plays a central role in the development of many phylogenetically diverse organisms including Drosophila, Caenorhabditis elegans, Xenopus, and higher vertebrates. In addition, genetic alterations of components in the pathway are associated with tumorigenesis in mice and humans, particularly melanomas and carcinomas of the breast and colon.
Grant D. Barish, Bart O. Williams
openaire +1 more source
An arrow hits the Wnt signaling pathway
Trends in Neurosciences, 2001A recent series of papers in Nature shows that low-density lipoprotein receptor-related protein family members play a role in transduction of Wnt signals. These findings, in addition to other work from the past two years, have important implications for the role of Wnts in neural development.
openaire +2 more sources
Non-canonical Wnt signaling pathways in hematopoiesis
Immunologic Research, 2009Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-long generation of blood cells of all lineages. In order to maintain their numbers, HSCs must establish a balance between the opposing cell fates of self-renewal and initiation of hematopoietic differentiation.
Kathleen, Kokolus, Michael J, Nemeth
openaire +2 more sources
[Wnt signaling pathways and osteoarthritis].
Zhongguo gu shang = China journal of orthopaedics and traumatology, 2010The Wnt signaling exists in every kinds of species and regulates a variety of biological processes including cell fate, proliferation and function, immunity, stress, apoptosis and so on. During the researching, Wnt signaling also plays an important role in chondrocyte differentiation and maturation.
Ning-Yang, Gao +5 more
openaire +1 more source
The Wnt Signaling Pathway in Retinal Degenerations
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005The retina is a complex tissue composed of multiple interconnected cell layers, highly specialized for transforming light and color into electrical signals perceived by the brain. Damage or death of the primary light-sensing cells, the photoreceptors, results in devastating effects on vision.
openaire +2 more sources
The Canonical Wnt/β-Catenin Signalling Pathway
2008Embryonic development of multicellular organisms is an incredibly complex process that relies heavily on evolutionarily conserved signalling pathways to provide crucial cell-cell communication. Typically, secreted signalling proteins such as Wnts, BMPs, and Hedgehogs released by one cell population will trigger concentration-dependent responses in ...
openaire +2 more sources