Results 1 to 10 of about 46 (46)
Cryo-EM structure of human Wntless in complex with Wnt3a
Nature Communications, 2021 The transmembrane protein Wntless (WLS) is essential for the secretion of Wnt proteins, which are signaling molecules of the Wnt signaling pathways. Here, the authors present the 2.2 Å cryo-EM structure of human WLS in complex with Wnt3a and discuss ...
Qing Zhong +17 more
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Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. [PDF]
PLoS ONE, 2015 The mammalian serum- and glucocorticoid-inducible kinase SGK1 regulates the endocytosis of ion channels. Here we report that in C. elegans sgk-1 null mutants, GFP-tagged MIG-14/Wntless, the sorting receptor of Wnt, failed to localize to the basolateral ...
Ming Zhu +6 more
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A stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche
BMC Biology, 2023 Background The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure.
Jinnan Xiang +7 more
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Novel Dental Anomaly–associated Mutations in WNT10A Protein Binding Sites
International Dental Journal, 2023 Objective: WNT/β-catenin signaling is initiated by binding of a WNT protein to a Frizzled (FZD) receptor and a co-receptor, low-density lipoprotein (LDL) receptor-related protein 5 or 6 (LRP5/6).
Piranit Kantaputra +8 more
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WLS-Wnt signaling promotes neuroendocrine prostate cancer
iScience, 2021 Summary: Neuroendocrine prostate cancer (NEPC) is a lethal prostate cancer subtype arising as a consequence of more potent androgen receptor (AR) targeting in castration-resistant prostate cancer (CRPC). Its molecular pathogenesis remains elusive.
Tyler Bland +8 more
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Molecular Metabolism, 2020 Objective: Obesity is a key risk factor for many secondary chronic illnesses, including type 2 diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is established as an important endogenous inhibitor of adipogenesis.
Devika P. Bagchi +9 more
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Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice. [PDF]
PLoS ONE, 2012 Wnt proteins are secreted molecules that play multiple roles during hair follicle development and postnatal hair cycling. Wntless (Wls) is a cargo protein required for the secretion of various Wnt ligands.
Sixia Huang +7 more
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Frontiers in Cell and Developmental Biology, 2021 Proper differentiation of odontoblasts is crucial for the development of tooth roots. Previous studies have reported the osteogenic/odontogenic potential of pre-odontoblasts during root odontoblast differentiation.
Ran Zhang +8 more
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Functional characterization of mammalian Wntless homolog in mammalian system
Kaohsiung Journal of Medical Sciences, 2012 Wntless (GPR177) protein is a newly identified regulator of Wnt signals in Drosophila, but its cellular function in mammals is still unclear. In this study, we explored the expression pattern and potential cellular function of Wntless in mammalian cells.
Li-Ting Wang +2 more
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TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction
Frontiers in Cell and Developmental Biology, 2020 Wnt signaling pathway plays indispensable roles in embryonic development and adult tissue homeostasis. However, the regulatory mechanisms involved in Wnt ligand trafficking within and secretion from the signal sending cells is still relatively ...
Binbin Li, Lee A. Niswander
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