Results 91 to 100 of about 115 (110)
Wntless promotes pulmonary differentiation and growth
Developmental Biology, 2011 Sinner, Debora +3 more
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Scientific ReportsXerostomia, the subjective sensation of dry mouth, is a debilitating consequence of head and neck radiotherapy and autoimmune disorders such as Sjögren’s syndrome.
Araz Ahmed +3 more
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Wntless activates AR/AR variants and confers resistance to AR-targeted therapy in CRPC
European Urology Open Science, 2020 A. Gao +7 more
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Mechanisms of Wntless trafficking and Wnt signaling
, 2014 Cell to cell communication is essential during development of all animals. Several intercellular communication mechanisms have evolved, the Wnt signaling pathway is one of these communication mechanisms. Wnt signaling is required for embryonic development and adult tissue homeostasis. Misregulation of Wnt signaling can cause disease, most notably colon
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Sprinter/Wntless is an escort factor for Wg deployment
Developmental Biology, 2008 Selva, Erica M. +2 more
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Investigation on Wntless to regulate dendritic development in cerebellar Purkinje cells
Mechanisms of Development, 2017 Yue Hu, Kin Ming Kwan
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The Crucial Role of Wntless in Osteogenesis and Odontogenesis.
The Chinese journal of dental research, 2021Wnt signalling pathways have been the focus of intense research activity for decades due to their fundamental role in skeletal and dental development. Wntless, an exclusive chaperone protein for the exocytotis of Wnt ligands, was identified in 2006. In the last decade, the molecular biological studies of Wntless and its genetic studies in human and ...
Jia Hui, Du +2 more
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Porcupine/Wntless‐dependent trafficking of the conserved WntA ligand in butterflies
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2021AbstractWnt ligands are key signaling molecules in animals, but little is known about the evolutionary dynamics and mode of action of the WntA orthologs, which are not present in the vertebrates or in Drosophila. Here we show that the WntA subfamily evolved at the base of the Bilateria + Cnidaria clade, and conserved the thumb region and Ser209 ...
Joseph J. Hanly +3 more
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Wingless secretion promotes and requires retromer-dependent cycling of Wntless
Nature Cell Biology, 2008Wnt ligands are lipid-modified, secreted glycoproteins that control multiple steps during embryogenesis and adult-tissue homeostasis. Little is known about the mechanisms underlying Wnt secretion. Recently, Wntless (Wls/Evi/Srt) was identified as a conserved multi-pass transmembrane protein whose function seems to be dedicated to promoting the release ...
Port, F +6 more
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Protein kinase CK2 is required for Wntless internalization and Wnt secretion
Cellular Signalling, 2014Wnt proteins are lipid modified signaling molecules that have essential functions in development and adult tissue homeostasis. Secretion of Wnt is mediated by the transmembrane protein Wntless, which binds Wnt and transports it from the endoplasmic reticulum to the cell surface for release.
de Groot, Reinoud E A +3 more
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