Results 101 to 110 of about 115 (110)

Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses

Cellular Signalling, 2021
The WNT (Wingless and Int-1) proteins play a role in stem cell development and cell differentiation. Mutations in the WNT proteins lead to the development of various tumours, including gastric tumours. Porcupine (PORCN) is a palmitoyltransferase and Wntless (WLS) is a dedicated WNT transport protein that modify and fold the WNT proteins respectively ...
Rowida, Mohamed, Catherine, Kennedy, William G, Willmore   +2 more
openaire   +2 more sources

Identifying the dynamic oligomerization of Wntless

2016
Wnt proteins are a highly conserved family of secreted glycoproteins that act as ligands in receptor-mediated signaling pathways. These complex pathways are present, and tightly regulated, at various stages of development including early embryonic patterning, cell fate decisions, and proliferation of stem cells.
openaire   +1 more source

Involvement of epithelial Wntless in the regulation of postnatal hair follicle morphogenesis

Archives of Dermatological Research, 2015
The roles of the Wnt cargo receptor Wntless (Wls) during hair follicle (HF) induction and postnatal HF cycling in skin have been elucidated. However, whether Wls regulates postnatal HF morphogenesis remains unclear. In this study, we found that Wls is expressed in developing HF during the morphogenesis stage after birth.
Sixia, Huang, Xuming, Zhu, Yixin, Tao, Qianqian, Sun, Lei, Wang, Baojie, Li, Lin, He, Xizhi, Guo, Gang, Ma   +8 more
openaire   +2 more sources

Structural and functional analysis of Wntless in Wnt signaling

2015
Wnt signal transduction plays important roles in numerous phases of organismal development and tissue homeostasis. When aberrant, Wnt signaling can drive cell transformation that results in cancer and various developmental diseases. Over the years, it has become clear that Wnt activity is strictly regulated, not only in signal-receiving cells, but also
openaire   +2 more sources

[Sorting, recycling and WNT signaling: Wntless and retromer functions].

Medecine sciences : M/S, 2010
Cell-cell signaling is essential for the development of multi-cellular organisms. Indeed, membrane traffic is required for the correct sorting and function of receptors and ligands. In the past decades, many genetic screens performed in C. elegans and Drosophila have been crucial to identify the role of intracellular traffic in signaling.
Grégoire, Michaux, Roland, Le Borgne
openaire   +1 more source

Supplemental magnesium gluconate recovers osteoblastic Wntless ablation-induced degenerative bone complications

Journal of Bone and Mineral Metabolism
Although numerous studies have highlighted the involvement of Wnt-mediated signaling in Mg ion-enhanced bone healing, whether Wnt-stimulated signaling is essential for the Mg ion-triggered bone repair and mass accrual is not yet completely understood.We generated Wlsfl/fl wild-type (WT) control and their corresponding mutant (MT), Col2.3-Cre;Wlsfl/fl ...
Govinda Bhattarai, Ju-Hyeon An, Shankar Rijal, Junil Lee, Junhyeok Kim, Sung-Ho Kook, Jeong-Chae Lee, Eui-Sic Cho   +7 more
openaire   +2 more sources

EYA protein complex is required for Wntless retrograde trafficking from endosomes to Golgi

Developmental Cell
Retrograde transport of WLS (Wntless) from endosomes to trans-Golgi network (TGN) is required for efficient Wnt secretion during development. However, the molecular players connecting endosomes to TGN during WLS trafficking are limited. Here, we identified a role for Eyes Absent (EYA) proteins during retrograde trafficking of WLS to TGN in human cell ...
Hilal Ahmad Reshi, Raghavender Medishetti, Aishwarya Ahuja, Deepa Balasubramanian, Kavita Babu, Manish Jaiswal, Kiranam Chatti, Subbareddy Maddika   +7 more
openaire   +3 more sources

EYA Proteins Couple Endosomes With Golgi During Wntless Trafficking

SSRN Electronic Journal, 2022
Hilal Ahmad Reshi, Subbareddy Maddika
openaire   +1 more source

CaSR covalently modifies Wntless (Wls) to differentially regulate Wnt5a and Wnt3a secretion

Bone, 2012
P. Lungchukiet, J.E. Kelly, I. Pacheco, R.J. MacLeod   +3 more
openaire   +1 more source

Tri sélectif et recyclage : Wntless et le retromer, deux acteurs clés de la signalisation WNT [Sorting, recycling and WNT signaling: Wntless and retromer functions]

2009
Michaux, Grégoire, Le Borgne, Roland
openaire   +1 more source