Results 11 to 20 of about 115 (110)
JBMR Plus, 2023 GαS, the stimulatory G protein α‐subunit that raises intracellular cAMP levels by activating adenylyl cyclase, plays a vital role in bone development, maintenance, and remodeling. Previously, using transgenic mice overexpressing GαS in osteoblasts (GS‐Tg)
Kathy K Lee +3 more
doaj +2 more sources
Epithelial Wntless regulates postnatal alveologenesis
Development, 2022 ABSTRACT Alveologenesis requires the coordinated modulation of the epithelial and mesenchymal compartments to generate mature alveolar saccules for efficient gas exchange. However, the molecular mechanisms underlying the epithelial-mesenchymal interaction during alveologenesis are poorly understood.
Yinshan Fang +6 more
openaire +2 more sources
The role of Evi/Wntless in exporting Wnt proteins
Development, 2023 ABSTRACTIntercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans. Many context-dependent effects are initiated in the Wnt-producing cells and depend on the export of lipidated Wnt proteins.
Lucie Wolf, Michael Boutros
openaire +2 more sources
Concentration‐dependent effects of WNTLESS on WNT1/3A signaling [PDF]
Developmental Dynamics, 2014 Background: WNTLESS (WLS) is a multi‐transmembrane protein that transports Wnt ligands from the Golgi to the cell surface. Although WLS loss‐of‐function experiments in the developing central nervous system reveal phenotypes consistent with defects in WNT1 and WNT3A signaling, data from complementary gain‐of‐function experiments have not yet been ...
Lisa M, Galli +5 more
openaire +2 more sources
Wntless functions in mature osteoblasts to regulate bone mass [PDF]
Proceedings of the National Academy of Sciences, 2012 Recent genome-wide association studies of individuals of Asian and European descent have found that SNPs located within the genomic region (1p31.3) encoding the Wntless (Wls)/Gpr177 protein are associated significantly with reduced bone mineral density.
Zhendong, Zhong +11 more
openaire +2 more sources
Wntless in Wnt secretion: molecular, cellular and genetic aspects [PDF]
Frontiers in Biology, 2012 Throughout the animal kingdom, Wnt-triggered signal transduction pathways play fundamental roles in embryonic development and tissue homeostasis. Wnt proteins are modified as glycolipoproteins and are secreted into the extracellular environment as morphogens. Recent studies on the intracellular trafficking of Wnt proteins demonstrate multiple layers of
Soumyashree, Das +4 more
openaire +2 more sources
Molecular Carcinogenesis, Volume 62, Issue 9, Page 1312-1324, September 2023., 2023 Abstract Abiraterone acetate has been clinically approved for the treatment of patients with advanced‐stage prostate cancer. It reduces testosterone production by blocking the enzyme cytochrome P450 17 alpha‐hydroxylase. Despite improved survival outcomes with abiraterone, almost all patients develop therapeutic resistance and disease recurrence ...
Ibrahim M. Atawia +6 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 7, Page 4155-4169, July 2023., 2023 Natural products have been known to have important therapeutic properties. Glycyrrhizic acid, solanine, polyphyllin I, crocin, hypericin, tubeimoside‐1, diosmin, and rutin could serve as scaffolds or leads for new anticancer therapy/drug. Abstract Wnt/β‐catenin signaling pathway plays a role in cancer development, organogenesis, and embryogenesis.
Chukwuebuka Egbuna +11 more
wiley +1 more source
Design of Nanohydrogels for Targeted Intracellular Drug Transport to the Trans‐Golgi Network
Advanced Healthcare Materials, Volume 12, Issue 13, May 19, 2023., 2023 The design of polyglycidol‐based nanohydrogels for selective organelle targeting of therapeutic agents is reported with the example of the targeted retrograde transport of the antidiabetic peptide RS1‐reg to its site of action at the trans‐Golgi network, demonstrating that endosomal escape is not always required for specific intracellular drug ...
Thorsten Keller +9 more
wiley +1 more source
JOR SPINE, Volume 6, Issue 1, March 2023., 2023 In this review, we described the development process and principles of the gene knockout technologies, functions of the edited genes in disc degeneration, advantages and disadvantages of different methods and possible targets of the specific Cre recombinase in intervertebral discs.
Ze‐Yu Lu +6 more
wiley +1 more source