Results 21 to 30 of about 115 (110)

Retromer Retrieves Wntless [PDF]

Developmental Cell, 2008
Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.
openaire   +3 more sources

Between a rock and a hard place: Regulation of mineralization in the periodontium

genesis, Volume 60, Issue 8-9, September 2022., 2022
Summary The periodontium supports and attaches teeth via mineralized and nonmineralized tissues. It consists of two, unique mineralized tissues, cementum and alveolar bone. In between these tissues, lies an unmineralized, fibrous periodontal ligament (PDL), which distributes occlusal forces, nourishes and invests teeth, and harbors progenitor cells for
Natalie L. Andras, Fatma F. Mohamed, Emily Y. Chu, Brian L. Foster   +3 more
wiley   +1 more source

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless [PDF]

Cell, 2009
Wnts play pivotal roles during development and in the mature nervous system. However, the mechanism by which Wnts traffic between cells has remained elusive. Here we demonstrate a mechanism of Wnt transmission through release of exosome-like vesicles containing the Wnt-binding protein Evenness Interrupted/Wntless/Sprinter (Evi/Wls/Srt). We show that at
Korkut, Ceren, Ataman, Bulent, Ramachandran, Preethi, Ashley, James A., Barria, Romina, Gherbesi, Norberto G., Budnik, Vivian   +6 more
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An insight into planarian regeneration

Cell Proliferation, Volume 55, Issue 9, September 2022., 2022
Genetic and molecular mechanisms for regeneration control on various tissues in planarian. Abstract Background Planarian has attracted increasing attentions in the regeneration field for its usefulness as an important biological model organism attributing to its strong regeneration ability.
Xin‐Yang Ge, Xiao Han, Yong‐Liang Zhao, Guan‐Shen Cui, Yun‐Gui Yang   +4 more
wiley   +1 more source

Loss of Macrophage Wnt Secretion Improves Remodeling and Function After Myocardial Infarction in Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundMacrophages and Wnt proteins (Wnts) are independently involved in cardiac development, response to cardiac injury, and repair. However, the role of macrophage‐derived Wnts in the healing and repair of myocardial infarction (MI) is unknown.
Dahlia Palevski, La‐Paz Levin‐Kotler, David Kain, Nili Naftali‐Shani, Natalie Landa, Tammy Ben‐Mordechai, Tal Konfino, Radka Holbova, Natali Molotski, Rina Rosin‐Arbesfeld, Richard A. Lang, Jonathan Leor   +11 more
doaj   +1 more source

Endothelial Wnts control mammary epithelial patterning via fibroblast signaling

Cell Reports, 2021
Summary: Endothelial and fibroblast niches are crucial for epithelial organs. How these heterotypic cells interact is of great interest. In this study, we reveal an axis of signaling in which fibroblasts relay Wnt signals from the endothelial niche to ...
Jingqiang Wang, Wenqian Song, Ruikai Yang, Chao Li, Ting Wu, Xiao Bing Dong, Bin Zhou, Xizhi Guo, Jianfeng Chen, Zhiyong Liu, Qing Cissy Yu, Wen Li, Junfen Fu, Yi Arial Zeng   +13 more
doaj   +1 more source

Distinct requirements for Wntless in habenular development

Developmental Biology, 2015
Secreted Wnt proteins play pivotal roles in development, including regulation of cell proliferation, differentiation, progenitor maintenance and tissue patterning. The transmembrane protein Wntless (Wls) is necessary for secretion of most Wnts and essential for effective Wnt signaling.
Kuan, Yung-Shu, Roberson, Sara, Akitake, Courtney M., Fortuno, Lea, Gamse, Joshua, Moens, Cecilia, Halpern, Marnie E.   +6 more
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Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models [PDF]

Biochemical and Biophysical Research Communications, 2019
Wnt signaling is essential for the maintenance of adult stem cells and its aberrant activation is a stimulator of carcinogenesis. The transmembrane protein, Wntless, is an essential Wnt signaling component through regulating the secretion of Wnt ligands.
Ganglong, Gao, Gaigai, Wei, Shijie, Liu, Jiwei, Chen, Zhiyang, Zeng, Xinyan, Zhang, Fangrui, Chen, Lingang, Zhuo, Wei, Hsu, Dali, Li, Mingyao, Liu, Xueli, Zhang   +11 more
openaire   +2 more sources

Structural and molecular characterization of paraventricular thalamic glucokinase‐expressing neuronal circuits in the mouse

Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022
By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari, Simon Quenneville, Ana Rodriguez Sanchez‐Archidona, Bernard Thorens, Sophie Croizier   +4 more
wiley   +1 more source

A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Rhizoma Dioscoreae Nipponicae in the Treatment of Asthma

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. In this study, network pharmacological methods were used to analyze the targets of Rhizoma Dioscoreae Nipponicae (RDN) and investigate the potential underlying mechanism of RDN in the treatment of asthma. Methods. Asthma‐related targets were obtained from the GeneCards and DisGeNET databases.
Weiyi Wang, Liying Xu, Lingming Zhou, Shanhong Wan, Libin Jiang, Mozaniel Oliveira   +5 more
wiley   +1 more source