Results 31 to 40 of about 115 (110)
Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters
Membranes, 2015 Transport between the endoplasmatic reticulum, the Golgi-network, the endo-lysosomal system and the cell surface can be categorized as anterograde or retrograde, describing traffic that goes forward or backward, respectively.
Stine C. Klinger +2 more
doaj +1 more source
MON2 Guides Wntless Transport to the Golgi through Recycling Endosomes
Cell Structure and Function, 2020 Endocytic cargos are transported to recycling endosomes (RE) but how these sorting platforms are generated is not well understood. Here we describe our biochemical and live imaging studies of the conserved MON2-DOPEY complex in RE formation. MON2 mainly co-localized with RE marker RAB4B in peripheral dots and perinuclear region.
Zhao, Shen-Bao +3 more
openaire +3 more sources
Nature Communications, 2018 Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C.
Ian J. McGough +8 more
doaj +1 more source
Wnt-Dependent Activation of ERK Mediates Repression of Chondrocyte Fate during Calvarial Development
Journal of Developmental Biology, 2021 Wnt signaling regulates cell fate decisions in diverse contexts during development, and loss of Wnt signaling in the cranial mesenchyme results in a robust and binary cell fate switch from cranial bone to ectopic cartilage.
Beatriz A Ibarra +2 more
doaj +1 more source
Cell Reports, 2018 Summary: Wnt/β-catenin signaling is necessary for lymphatic vascular development. Oscillatory shear stress (OSS) enhances Wnt/β-catenin signaling in cultured lymphatic endothelial cells (LECs) to induce expression of the lymphedema-associated ...
Boksik Cha +16 more
doaj +1 more source
Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature. [PDF]
PLoS ONE, 2017 Resident tissue myeloid cells play a role in many aspects of physiology including development of the vascular systems. In the blood vasculature, myeloid cells use VEGFC to promote angiogenesis and can use Wnt ligands to control vascular branching and to ...
Ajit Muley +7 more
doaj +1 more source
eLife, 2020 In the hippocampus, a widely accepted model posits that the dentate gyrus improves learning and memory by enhancing discrimination between inputs. To test this model, we studied conditional knockout mice in which the vast majority of dentate granule ...
Amir Rattner +14 more
doaj +1 more source
Generation of mice with a conditional null allele for Wntless [PDF]
genesis, 2010 AbstractThe Wnt‐signaling pathway is necessary in a variety of developmental processes and has been implicated in numerous pathologies. Wntless (Wls) binds to Wnt proteins and facilitates Wnt sorting and secretion. Conventional deletion of Wls results in early fetal lethality due to defects in body axis establishment.
April C, Carpenter +4 more
openaire +2 more sources
Wntless Regulates Dentin Apposition and Root Elongation in the Mandibular Molar [PDF]
Journal of Dental Research, 2015 Wnt signaling plays an essential role in the dental epithelium and mesenchyme during tooth morphogenesis. However, it remains unclear if Wnt ligands, produced from dental mesenchyme, are necessary for odontoblast differentiation and dentin formation. Here, we show that odontoblast-specific disruption of Wntless (Wls), a chaperon protein that regulates
C H, Bae +5 more
openaire +2 more sources
Wntless Is Highly Expressed in Advanced-Stage Intrahepatic Cholangiocarcinoma
The Tohoku Journal of Experimental Medicine, 2018 Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy of the bile duct, representing the second most common primary liver cancer. Wntless (Wls) is a highly conserved transmembrane protein that shuttles palmitoylated Wnt proteins from the endoplasmic reticulum to the plasma membrane. Wls is highly expressed in various types of cancers and is
Yi, Shi +3 more
openaire +3 more sources