Results 41 to 50 of about 115 (110)
Inhibition of Wntless/GPR177 suppresses gastric tumorigenesis
BMB Reports, 2018 Wntless/GPR177 functions as WNT ligand carrier protein and activator of WNT/β-catenin signaling, however, its molecular role in gastric cancer (GC) has remained elusive. We investigated the role of GPR177 in gastric tumorigenesis and provided the therapeutic potential of a clinical development of anti-GPR177 monoclonal antibodies.
Seo, Jaesung +14 more
openaire +3 more sources
eLife, 2017 Commissural axons switch on responsiveness to Wnt attraction during midline crossing and turn anteriorly only after exiting the floor plate. We report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the ...
Keisuke Onishi, Yimin Zou
doaj +1 more source
EMBO Molecular Medicine, 2012 Elevated levels of nuclear β‐catenin are associated with higher rates of survival in patients with melanoma, raising questions as to how ß‐catenin is regulated in this context.
Pei‐Tzu Yang +7 more
doaj +1 more source
Cell Reports, 2016 Targeting of Wnt signaling represents a promising anti-cancer therapy. However, the consequences of systemically attenuating the Wnt pathway in an adult organism are unknown. Here, we globally prevent Wnt secretion by genetically ablating Wntless.
Tomas Valenta +9 more
doaj +1 more source
Divergent effects of Porcupine and Wntless on WNT1 trafficking, secretion, and signaling [PDF]
Experimental Cell Research, 2016 Loss-of-function studies have identified Porcupine (PORCN) and Wntless (WLS) as essential mediators of Wnt secretion and signaling. Whereas PORCN is thought to palmitoylate Wnt proteins, WLS is believed to transport palmitoylated Wnt proteins to the cell surface.
Galli, Lisa M +4 more
openaire +4 more sources
SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless [PDF]
Cell Research, 2011 Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently identified retromer as a key regulator involved in Wls trafficking. As sorting nexin (SNX) molecules are essential components of the retromer complex, we hypothesized that specific SNX(s) is ...
Zhang, Peng +3 more
openaire +2 more sources
Advancement of Wnt signal pathway and the target of breast cancer
Open Life Sciences, 2016 Wnt/β-catenin signaling has been proved to play an important role in the development and promotion of cancer metastasis. The activation of Wnt signals can lead to duplicating, updating, metastasizing and relapsing.
Liang Quan +3 more
doaj +1 more source
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans. [PDF]
PLoS ONE, 2016 Retrograde transport is a critical mechanism for recycling certain membrane cargo. Following endocytosis from the plasma membrane, retrograde cargo is moved from early endosomes to Golgi followed by transport (recycling) back to the plasma membrane.
Donglei Zhang +3 more
doaj +1 more source
Wntless spatially regulates bone development through β‐catenin–dependent and independent mechanisms [PDF]
Developmental Dynamics, 2015 Background: Canonical and noncanonical Wnt signaling pathways both play pivotal roles in bone development. Wntless/GPR177 is a chaperone protein that is required for secretion of all Wnt ligands. We previously showed that deletion of Wntless within mature osteoblasts severely impaired postnatal bone homeostasis.
Zhendong A, Zhong +5 more
openaire +2 more sources
Reduced Growth and Inflammation in Lrp5−/− Mice Adipose Tissue
Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.ABSTRACT Obesity is a major cause of chronic disease morbidity–mortality. Understanding the mechanisms triggering its promotion will allow the development of effective treatments. Cardiovascular diseases are associated with high‐fat diet ingestion; however, how adiposity is distributed in relation to fat intake is not known.
Aureli Luquero +4 more
wiley +1 more source