Results 51 to 60 of about 115 (110)

Gpr177/mouse Wntless is essential for Wnt‐mediated craniofacial and brain development [PDF]

Developmental Dynamics, 2011
AbstractWe have previously demonstrated that Gpr177, the mouse orthologue of Drosophila Wls/Evi/Srt, is required for establishment of the anterior–posterior axis. The Gpr177 null phenotype is highly reminiscent to the loss of Wnt3, the earliest abnormality among all Wnt knockouts in mice.
Jiang, Fu, Hsiao-Man, Ivy Yu, Takamitsu, Maruyama, Anthony J, Mirando, Wei, Hsu   +4 more
openaire   +2 more sources

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source

Ehbp1 orchestrates orderly sorting of Wnt/Wingless to the basolateral and apical cell membranes

EMBO Reports
Wingless (Wg)/Wnt signaling plays a critical role in both development and adult tissue homeostasis. In the Drosophila larval wing disc epithelium, the orderly delivery of Wg/Wnt to the apical and basal cell surfaces is essential for wing development ...
Yuan Gao, Jing Feng, Yansong Zhang, Mengyuan Yi, Lebing Zhang, Yan Yan, Alan Jian Zhu, Min Liu   +7 more
doaj   +1 more source

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. [PDF]

PLoS ONE, 2013
In C. elegans and Drosophila, retromer mediated retrograde transport of Wntless (Wls) from endosomes to the trans-Golgi network (TGN) is required for Wnt secretion.
Reinoud E A de Groot, Henner F Farin, Marie Macůrková, Johan H van Es, Hans C Clevers, Hendrik C Korswagen   +5 more
doaj   +1 more source

Xenopus Wntless and the Retromer Complex Cooperate To Regulate XWnt4 Secretion [PDF]

Molecular and Cellular Biology, 2009
Wnt signaling is implicated in a variety of developmental and pathological processes. The molecular mechanisms governing the secretion of Wnt ligands remain to be elucidated. Wntless, an evolutionarily conserved multipass transmembrane protein, is a dedicated secretion factor of Wnt proteins that participates in Drosophila melanogaster embryogenesis ...
Kim, H, Cheong, SM, Ryu, J, Jung, HJ, Jho, EH, Han, JK   +5 more
openaire   +3 more sources

WNT5a export onto extracellular vesicles studied at single‐molecule and single‐vesicle resolution

The FEBS Journal, Volume 292, Issue 17, Page 4631-4649, September 2025.
WNT signaling, which orchestrates tissue development and homeostasis, is mediated by hydrophobic WNT proteins traveling from secreting to receiving cells on various carriers. Here, fusion constructs of fluorescent proteins with WNT5a were developed and functionally validated.
Antonia Schubert, Ajaree Mongkolsittisilp, Andrei Kobitski, Matthias Schulz, Oksana Voloshanenko, Meike Schaffrinski, Nadine Winkler, Michelle Neßling, Karsten Richter, Dominique Kranz, Karin Nienhaus, Dirk Jäger, Lorenz Trümper, Judith Büntzel, Claudia Binder, Gerd Ulrich Nienhaus, Michael Boutros   +16 more
wiley   +1 more source

Wntless is required for peripheral lung differentiation and pulmonary vascular development

Developmental Biology, 2013
Wntless (Wls), a gene highly conserved across the animal kingdom, encodes for a transmembrane protein that mediates Wnt ligand secretion. Wls is expressed in developing lung, wherein Wnt signaling is necessary for pulmonary morphogenesis. We hypothesize that Wls plays a critical role in modulating Wnt signaling during lung development and therefore ...
Cornett, Bridget, Snowball, John, Varisco, Brian M., Lang, Richard, Whitsett, Jeffrey, Sinner, Debora   +5 more
openaire   +2 more sources

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, Volume 35, Issue 29, July 17, 2025.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Structural Features of Glypicans and Their Impact on Wnt Signaling in Cancer

Proteoglycan Research, Volume 3, Issue 2, April 2025.
ABSTRACT Glypicans (GPCs) are a family of cell surface proteoglycans involved in multiple signaling pathways that regulate cell fate and proliferation. They share a characteristic structure composed of a core protein with two or more heparan sulfate chains and a glycosyl‐phosphatidylinositol anchor that attaches them to the cell membrane.
Hsi‐En Tsao, Mitchell Ho
wiley   +1 more source

Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions

BMC Molecular and Cell Biology, 2019
Background Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes.
Jessica Petko, Mathura Thileepan, Molly Sargen, Victor Canfield, Robert Levenson   +4 more
doaj   +1 more source