Results 61 to 70 of about 115 (110)
Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than HSCs maintenance [PDF]
European Journal of Immunology, 2015 Osteoblasts and perivascular stromal cells constitute essential niches for HSC self‐renewal and maintenance in the bone marrow. Wnt signaling is important to maintain HSC integrity. However, the paracrine role of Wnt proteins in osteoblasts‐supported HSC maintenance and differentiation remains unclear.
Jingjing, Cao +8 more
openaire +2 more sources
Developmental and genomic insight into the origin of the tardigrade body plan
Evolution &Development, Volume 26, Issue 4, July 2024.Three hypotheses for the homology of tardigrade segments to segments of other panarthropods. H, tardigrade head; T1‐T4, tardigrade trunk segment 1–trunk segment 4. Abstract Tardigrada is an ancient lineage of miniaturized animals. As an outgroup of the well‐studied Arthropoda and Onychophora, studies of tardigrades hold the potential to reveal ...
Frank W. Smith +5 more
wiley +1 more source
EBioMedicine, 2019 Background: Chromosomal translocation-induced expression of the chromatin modifying oncofusion protein MLL-AF9 promotes acute myelocytic leukemia (AML).
Li-shu Zhang +19 more
doaj +1 more source
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
PLoS Genetics, 2023 Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8).
Braveen B Joseph +9 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 28, Issue 12, June 2024.Abstract Hair follicle development and hair growth are regulated by multiple factors and multiple signalling pathways. The hair follicle, as an important skin appendage, is the basis for hair growth, and it has the functions of safeguarding the body, perceiving the environment and regulating body temperature. Hair growth undergoes a regular hair cycle,
Fanpan Du +5 more
wiley +1 more source
Wnt traffic from endoplasmic reticulum to filopodia.
PLoS ONE, 2019 Wnts are a family of secreted palmitoleated glycoproteins that play key roles in cell to cell communication during development and regulate stem cell compartments in adults.
Naushad Moti +4 more
doaj +1 more source
BMC Genomics, 2022 Background Insect metamorphosis from larvae to pupae is one of the most important stages of insect life history. Relatively comprehensive information related to gene transcription profiles during lepidopteran metamorphosis is required to understand the ...
Xinxin Gao +6 more
doaj +1 more source
The role of programmed cell death in osteosarcoma: From pathogenesis to therapy
Cancer Medicine, Volume 13, Issue 10, May 2024.Abstract Osteosarcoma (OS) is a prevalent bone solid malignancy that primarily affects adolescents, particularly boys aged 14–19. This aggressive form of cancer often leads to deadly lung cancer due to its high migration ability. Experimental evidence suggests that programmed cell death (PCD) plays a crucial role in the development of osteosarcoma ...
Suqing Liu +9 more
wiley +1 more source
Exploring Retrograde Trafficking: Mechanisms and Consequences in Cancer and Disease
Traffic, Volume 25, Issue 2, February 2024.Overview of the role of retrograde trafficking in disease and cancer. COPA, coatomer subunit α; ER, endoplasmic reticulum; HIV, human immunodeficiency virus; IFN, interferon; RTK, receptor tyrosine kinase; STING, stimulator of interferon genes. Created with BioRender.com.
Rachel Bingham +2 more
wiley +1 more source
BMC Neuroscience, 2010 Background Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR ...
Stagljar Igor +7 more
doaj +1 more source