Results 71 to 80 of about 115 (110)
Identifying novel members of the Wntless interactome through genetic and candidate gene approaches [PDF]
Brain Research Bulletin, 2018 Wnt signaling is an important pathway that regulates several aspects of embryogenesis, stem cell maintenance, and neural connectivity. We have recently determined that opioids decrease Wnt secretion, presumably by inhibiting the recycling of the Wnt trafficking protein Wntless (Wls).
Jessica, Petko +4 more
openaire +2 more sources
Golgi Phosphoprotein 3 Promotes Wls Recycling and Wnt Secretion in Glioma Progression
Cellular Physiology and Biochemistry, 2018 Background/Aims: Golgi phosphoprotein 3 (GOLPH3) plays pro-malignancy roles in several types of cancer. However, the molecular mechanism underlying GOLPH3 promoting tumor progression remains poorly understood.
Dong Lu +7 more
doaj +1 more source
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
PLoS ONE, 2012 Porcupine (PORCN) is a membrane-bound O-acyl transferase that is required for the palmitoylation of Wnt proteins, and that is essential in diverse Wnt pathways for Wnt-Wntless (WLS) binding, Wnt secretion, and Wnt signaling activity.
Tracy M Covey +6 more
doaj +1 more source
Wntless (Wls): A Prognostic Index for Progression and Patient Survival of Breast Cancer.
OncoTargets and therapy, 2020 Wntless (Wls) is an essential protein that is necessary for the secretion of Wnt proteins. While numerous researches have demonstrated that aberrations in Wnt/β-catenin expression lead to tumorigenesis and progression in many cancer types, the effects of Wls in breast cancer (BC) are less studied.The mRNA and protein expression of Wls in BC cell lines ...
Zheng,Dandan +9 more
openaire +3 more sources
iScienceSummary: Wnts are lipid-modified glycoproteins that play key roles in both embryonic development and adult homeostasis. Wnt signaling is dysregulated in many cancers and preclinical data shows that targeting Wnt biosynthesis and secretion can be ...
Jia Yu +5 more
doaj +1 more source
Aging, 2020 WNT proteins are widely expressed in the murine ovaries. WNTLESS is a regulator essential for all WNTs secretion. However, the complexity and overlapping expression of WNT signaling cascades have prevented researchers from elucidating their function in the ovary.
Cheng, Jinmei +5 more
openaire +2 more sources
Retromer disruption promotes amyloidogenic APP processing
Neurobiology of Disease, 2011 Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in ...
Christopher P. Sullivan +7 more
doaj +1 more source
Brain transcriptome variation among behaviorally distinct strains of zebrafish (
BMC Genomics, 2012 Background Domesticated animal populations often show profound reductions in predator avoidance and fear-related behavior compared to wild populations. These reductions are remarkably consistent and have been observed in a diverse array of taxa including
Drew Robert E +5 more
doaj +1 more source
Frontiers in Cell and Developmental BiologyApical constriction of epithelial cells usually occurs in a local portion of epithelial sheet, which results in bending of epithelial tissues. However, it is uncertain whether diffusible signal molecules, like Wnt, regulate such locally restricted events.
Takuma Shinozuka +7 more
doaj +1 more source
Frontiers in Immunology, 2018 Natural killer T (NKT) cells are prominent innate-like lymphocytes in the liver with critical roles in immune responses during infection, cancer, and autoimmunity.
Jessica C. Kling +16 more
doaj +1 more source