Results 31 to 40 of about 543,279 (297)

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Effects of long-term supplementation of chestnut and valonea extracts on methane release, digestibility and nitrogen excretion in sheep

Animal, 2014
The long-term effects of adding chestnut (CHE; Castanea sativa) and valonea (VAL; Quercus valonea) tannin-rich extracts to sheep feed were investigated. In Experiment 1, sheep (65 kg BW) were fed 842 g/day of a ryegrass-based hay.
G. Wischer, A.M. Greiling, J. Boguhn, H. Steingass, M. Schollenberger, K. Hartung, M. Rodehutscord   +6 more
doaj   +1 more source

Performance of a worm algorithm in $\phi^4$ theory at finite quartic coupling

, 2011
Worm algorithms have been very successful with the simulation of sigma models with fixed length spins which result from scalar field theories in the limit of infinite quartic coupling lambda.
Deng, Ingmar Vierhaus, Prokofʼev, Tomasz Korzec, Ulli Wolff, Vierhaus, Wolff, Wolff, Wolff, Wolff   +9 more
core   +1 more source

Influence of Bottom Electrodes on the Ferroelectric Stability of AlScN Film at High Temperatures

Advanced Electronic Materials, EarlyView.
The thermal stability of AlScN depends on the bottom electrode. When the bottom electrode possesses compressive stress, tensile strain develops in the AlScN upon thermal annealing, reducing the switching barrier. When the bottom electrode forms a coherent interface with AlScN, significant tensile strain and defects are generated in the AlScN layer ...
Kyung Do Kim, Seung Kyu Ryoo, Min Kyu Yeom, Dong Jae Kim, Cheol Seong Hwang   +4 more
wiley   +1 more source

Anesthetic management of a case of wolf-parkinson-white syndrome with rheumatic mitral stenosis presenting for cesarean section

Journal of Obstetric Anaesthesia and Critical Care, 2019
The occurrence of Wolff-Parkinson-White syndrome with rheumatic mitral stenosis is not only an uncommon entity, but also a complex scenario. Although anesthetic concerns in a parturient with Wolff-Parkinson-White syndrome have been addressed previously ...
Amit Jain, Indu Bala
doaj   +1 more source

Dynamic and static properties of the invaded cluster algorithm

, 1998
Simulations of the two-dimensional Ising and 3-state Potts models at their critical points are performed using the invaded cluster (IC) algorithm. It is argued that observables measured on a sub-lattice of size l should exhibit a crossover to Swendsen ...
C. F. Baillie, D. W. Heermann, J. Machta, J. Machta, J. Machta, J. Salas, K. Moriarty, L. Chayes, L. Y. Chayes, M. Aizenman, R. H. Swendsen, W. H. Press, X.-J. Li, X.-J. Li   +13 more
core   +1 more source

Proximity Ferroelectricity in Compositionally Graded Structures

Advanced Electronic Materials, EarlyView.
We perform the finite element modeling of the polarization switching in the compositionally graded AlN‐Al1‐xScxN and ZnO‐Zn1‐xMgxO structures and reveal the switching of spontaneous polarization in the whole structure in all these systems. The coercive field to switch is significantly lower than the electric breakdown field of the unswitchable AlN and ...
Eugene A. Eliseev, Anna N. Morozovska, Sergei V. Kalinin, Long‐Qing Chen, Venkatraman Gopalan   +4 more
wiley   +1 more source

The Fundamental Power of the Soul in Kant’s Reflections on Genius: Between the Influences of Tetens and Sulzer

Sententiae
In the Critique of Pure Reason, Kant addresses the problem of reason's supposition of a fundamental power underlying the faculties of cognition. This concept had been debated in seventeenth- and eighteenth-century philosophy. Kant's position in this work
Manuel Sánchez-Rodrígez, Sergii Secundant   +1 more
doaj   +1 more source

Sex-Dependent Estimation of Spinal Loads During Static Manual Material Handling Activities—Combined in vivo and in silico Analyses

Frontiers in Bioengineering and Biotechnology, 2021
Manual material handling (MMH) is considered as one of the main contributors to low back pain. While males traditionally perform MMH tasks, recently the number of females who undertake these physically-demanding activities is also increasing. To evaluate
Ali Firouzabadi, Navid Arjmand, Fumin Pan, Thomas Zander, Hendrik Schmidt   +4 more
doaj   +1 more source

Developing Tangible Data Literacies for the Internet of Tangible Things [PDF]

, 2018
This paper poses the question how to design tangible interactions with the Internet of Things (IoT) in a way that supports people to develop better mental models of the underlying cyber-physical systems and thus enrich the ways that people engage with ...
Giles, Emilie, Wolff, Annika
core