Results 71 to 80 of about 3,346,977 (142)
An artificial immune system for clustering amino acids in the context of protein function classification [PDF]
, 2009 This paper addresses the classification task of data mining (a form of supervised learning) in the context of an important bioinformatics problem, namely the prediction of protein functions.
Timmis, Jon +5 more
core +1 more source
Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus
Hippocampus, Volume 34, Issue 10, Page 528-539, October 2024.Abstract The hippocampus is considered essential for several forms of declarative memory, including spatial and social memory. Despite the extensive research of the classic subfields of the hippocampus, the fasciola cinerea (FC)—a medially located structure within the hippocampal formation—has remained largely unexplored.
Ioannis S. Zouridis +3 more
wiley +1 more source
European Journal of Neuroscience, Volume 60, Issue 5, Page 5040-5068, September 2024.A continuous crosstalk between the endoplasmic reticulum and mitochondria is essential for cellular homeostasis. Functional and structural alterations in these contact membrane regions are part of the pathological mechanism of many neurological disorders.
Ilaria Serangeli +3 more
wiley +1 more source
, 2003 Mutations of the WFS1 gene are responsible for Wolfram syndrome, a rare, recessive disorder characterized by early-onset, non-autoimmune diabetes mellitus, optic atrophy and further neurological and endocrinological abnormalities.
Hofmann, S;Philbrook, C;Gerbitz, KD;Bauer, MF
core
Calcium as a crucial cofactor for low density lipoprotein receptor folding in the endoplasmic reticulum [PDF]
, 2010 The family of low density lipoprotein (LDL) receptors mediate uptake of a plethora of ligands from the circulation and couple this to signaling, thereby performing a crucial role in physiological processes including embryonic development, cancer ...
Sub Cellular Protein Chemistry +6 more
core +2 more sources
The hope, hype and obstacles surrounding cell therapy
Journal of Cellular and Molecular Medicine, Volume 28, Issue 10, May 2024.Abstract Cell therapy offers hope, but it also presents challenges, most particularly the limited ability of human organs and tissues to regenerate. Since many diseases are associated with irreversible pathophysiological or traumatic changes, stem cells and their derivatives are unable to secure healing.
Cezary Tręda +2 more
wiley +1 more source
Protein-RNA interactions: a structural analysis [PDF]
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT +9 more
core
Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]
, 2006 Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core +1 more source
Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]
, 2007 An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core +1 more source
Frontiers in PediatricsIntroductionVasovagal syncope (VVS) is the most prevalent subtype of reflex syncope. However, the genetic etiology underlying familial recurrent VVS has not been fully elucidated.MethodsWe recruited a multigenerational Chinese pedigree with three ...
Xinxin Guo +4 more
doaj +1 more source