Results 31 to 40 of about 8,605,582 (300)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Lockdown Diaries of the Working Class

, 2022
Collated by the Working Class Collective, The Lockdown Diaries of the Working Class is a beautiful, self-published, illustrated book featuring the diaries of working class people from across the UK and their experiences of life during the first COVID19 ...
The Working Class Collective
core   +4 more sources

Violence against women in South Asia : subregional overview [PDF]

, 1999
The report attempts to compile a subregional overview of violence against women. The report has been prepared as a working paper for the subregional ESCAP Expert Group Meeting on Eliminating Violence Against Women held at Dhaka, Bangladesh from 14 to 16 ...
UN.ESCAP, Bangladesh. Women for Women
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Breastfeeding practices of working women

Curationis, 2002
Breastfeeding is the fundamental aspect of child rearing that a woman copes with. It creates a wonderful bond between mothers and their babies. The importance of breast feeding to child health is highlighted by the yearly World Breastfeeding week (Forste,
V.O. Netshandama
doaj   +1 more source

Knowledge attitudes and practice of breastmilk expression and storage among working mothers with infants under six months of age in Kenya

International Breastfeeding Journal, 2022
Background Expression and storage of breastmilk is a strategy that ensures continued breast milk consumption in the event of temporary separation of an infant from the mother.
Priscillah Wanini Edemba, Grace Irimu, Rachel Musoke   +2 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Women, work, and the academy [PDF]

Eos, Transactions American Geophysical Union, 2005
Harvard University President Lawrence Summers triggered an avalanche of media coverage and debate about the status of women in science in a 14 January 2005 speech. When Summers posited that the persistent absence of women in science could be due to a lack of “intrinsic aptitude” and an unwillingness to pursue high‐intensity academic careers, he placed ...
Bell, Robin E., Laird, Jennifer D.
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source