Results 51 to 60 of about 616,551 (309)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Career breaks of women due to family reasons: a long-term perspective using retrospective data [PDF]

open access: yes, 2004
In this article, we analyse whether family-related quits present long-term effects upon women's careers, and the magnitude of such effects. For this purpose, the impact of family-related breaks in the first ten years of their labour careers on three ...
Muñoz-Bullón, Fernando   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

The Development of Nominal Synsets for the Saraiki Language: A Corpus-based Analysis

open access: yesNUML Journal of Critical Inquiry
This paper focuses on developing nominal synsets for the Saraiki language (SL), a lesser-studied language spoken in Pakistan. Nominal synsets are groups of nouns that share semantic characteristics and are crucial for natural language processing tasks ...
Madya Asgher, Musarrat Azher
doaj   +1 more source

Epidemiology of dysmenorrhea among workers in Upper Egypt; A cross sectional study

open access: yesMiddle East Fertility Society Journal, 2018
Objective: To investigate the epidemiology of dysmenorrhea amongst women in two textile factories in Beni-Suef, Egypt compared to non-working controls. Study design: A cross sectional study. Setting: Beni-Suef, Egypt. Materials and methods: The study was
Ahmed E. Arafa   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Relating Factors for Depression in Korean Working Women: Secondary Analysis of the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V)

open access: yesAsian Nursing Research, 2015
Purpose: The purpose of this study was to investigate the health behaviors and risk factors for self-reported depression in Korean working women. Methods: This study adopted a secondary analysis from the fifth Korean National Health and Nutrition ...
Kyung-Jae Lee, MD, Jeung-Im Kim, RN, PhD
doaj   +1 more source

STUDY OF NUTRITIONAL STATUS& DIETARY PATTERN OF WORKING WOMEN AND NON-WORKING WOMEN OF JABALPUR

open access: yes, 2018
<p>Women are playing multiple roles in the family as a care giver mother and a money earner as well. Lack of time and strenuous pressure at work and home can affect their diet and health.
Sudha Tiwari*1 & Shweta Tripathi2
core   +1 more source

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