Results 61 to 70 of about 12,765,785 (291)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Validation of a deep neural network-based algorithm supporting clinical management of adnexal mass

Frontiers in Medicine, 2023
BackgroundConservative management of adnexal mass is warranted when there is imaging-based and clinical evidence of benign characteristics. Malignancy risk is, however, a concern due to the mortality rate of ovarian cancer. Malignancy occurs in 10–15% of
Gerard P. Reilly, Charles J. Dunton, Rowan G. Bullock, Daniel R. Ure, Herbert Fritsche, Srinka Ghosh, Todd C. Pappas, Ryan T. Phan   +7 more
doaj   +1 more source

Division of Women’s Health [PDF]

, 2018
This sheet describes the Division of Women’s Health, its mission, its goals and strategies and its focus areas and ...
South Carolina Department of Health and Environmental Control
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

High pregnancy incidence and low contraceptive use among a prospective cohort of female entertainment and sex workers in Phnom Penh, Cambodia

BMC Pregnancy and Childbirth, 2018
Background While HIV and unintended pregnancies are both occupational risks faced by female sex workers, the epidemiology of pregnancy and its drivers in this population remains understudied.
Putu Duff, Jennifer L. Evans, Ellen S. Stein, Kimberly Page, Lisa Maher, on behalf of the Young Women’s Health Study Collaborative   +5 more
doaj   +1 more source

Associations of ultrasound estimated early mid pregnancy visceral and subcutaneous fat depths and early pregnancy BMI with adverse neonatal outcomes

Scientific Reports, 2021
This study investigated whether maternal central adiposity and body mass index (BMI) were associated with neonatal hypoglycemia and adverse neonatal outcomes.
Emelie Lindberger, Anna-Karin Wikström, Eva Bergman, Karin Eurenius, Ajlana Mulic-Lutvica, Linda Lindström, Inger Sundström Poromaa, Fredrik Ahlsson   +7 more
doaj   +1 more source

Additional file 3: Figure S2. of Anthropometric measures and serum estrogen metabolism in postmenopausal women: the Womenâ s Health Initiative Observational Study

, 2017
Percentages of each pathway estrogens/estrogen metabolites (2-catechols, methylated 2-catechols, 4-catechols, methylated 4-catechols, 16-pathway metabolites) out of summed child estrogen metabolites by current BMI among current menopausal hormone therapy users. (PPTX 70 kb)
Oh, Hannah, Coburn, Sally, Matthews, Charles, Falk, Roni, LeBlanc, Erin, Wactawski-Wende, Jean, Sampson, Joshua, Pfeiffer, Ruth, Brinton, Louise, Wentzensen, Nicolas, Anderson, Garnet, Manson, JoAnn, Chen, Chu, Zaslavsky, Oleg, Xu, Xia, Trabert, Britton   +15 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Additional file 1: of Anticholinergic medication use and falls in postmenopausal women: findings from the womenâ s health initiative cohort study

, 2016
WHI Clinical Centers (DOCX 111 kb)
Marcum, Zachary, Wirtz, Heidi, Pettinger, Mary, LaCroix, Andrea, Carnahan, Ryan, Cauley, Jane, Bea, Jennifer, Gray, Shelly   +7 more
openaire   +1 more source