Results 71 to 80 of about 12,765,785 (291)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Impact of chemotherapy dose capping on treatment intensity and survival in early breast cancer patients with high body surface area

Archives of Gynecology and Obstetrics
Purpose This study evaluates treatment intensity, tolerability, and survival outcomes in early breast cancer patients with high body surface area (BSA) receiving capped chemotherapy doses.
A. Englisch, K. Eissler, D. Dannehl, J. Englisch, A. D. Hartkopf, S. Y. Brucker, E. M. Grischke, L. L. Volmer, T. Engler   +8 more
doaj   +1 more source

Effect of internet-based cognitive behaviour therapy among women with negative birth experiences on mental health and quality of life - a randomized controlled trial

BMC Pregnancy and Childbirth, 2022
Background Giving birth is often a positive experience, but 7–44% have negative experiences and about 4% develop posttraumatic stress disorder following childbirth (PTSD FC).
Josefin Sjömark, Agneta Skoog Svanberg, Margareta Larsson, Frida Viirman, Inger Sundström Poromaa, Alkistis Skalkidou, Maria Jonsson, Thomas Parling   +7 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

The adverse prognostic impact of reduced chemotherapy dose intensity appears attenuated in early breast cancer patients with treatment-relevant neutropenia: a retrospective cohort study

Archives of Gynecology and Obstetrics
Purpose Maintaining a relative dose intensity (RDI) ≥ 85% during chemotherapy is established as a critical threshold for optimal outcomes in early breast cancer.
K. Eissler, T. Engler, D. Dannehl, B. Schönfisch, J. Englisch, A. D. Hartkopf, S. Y. Brucker, E. M. Grischke, L. L. Volmer, Alexander Englisch   +9 more
doaj   +1 more source

Extending access to a web-based mental health intervention: who wants more, what happens to use over time, and is it helpful? Results of a concealed, randomized controlled extension study

BMC Psychiatry, 2019
Background Web-based mental health applications may be beneficial, but adoption is often low leaving optimal implementation and payment models unclear. This study examined which users were interested in extended access to a web-based application beyond ...
Jennifer M. Hensel, James Shaw, Noah M. Ivers, Laura Desveaux, Simone N. Vigod, Zachary Bouck, Nike Onabajo, Payal Agarwal, Geetha Mukerji, Rebecca Yang, Megan Nguyen, Lianne Jeffs, Trevor Jamieson, R. Sacha Bhatia   +13 more
doaj   +1 more source

Additional file 1: of Womenâ s perspectives on health facility and system levels factors influencing mode of delivery in Tehran: a qualitative study

, 2019
Annex 1. COREQ (COnsolidated criteria for REporting Qualitative research) Checklist. (PDF 423 kb)
Mahboube Shirzad, Shakibazadeh, Elham, Betran, Ana, Bohren, Meghan, Mehrandokht Abedini   +4 more
openaire   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Additional file 2: of Womenâ s perspectives on health facility and system levels factors influencing mode of delivery in Tehran: a qualitative study

, 2019
Annex 2. Interview Guide. (DOCX 15 kb)
Mahboube Shirzad, Shakibazadeh, Elham, Betran, Ana, Bohren, Meghan, Mehrandokht Abedini   +4 more
openaire   +1 more source

Additional file 1: of Womenâ s recall of health care provider counselling on gestational weight gain (GWG): a prospective, population-based study

, 2019
Figure S1. Distribution of GWG stratified by pre-pregnancy BMI. (DOCX 126 kb)
Vinturache, Angela, Winn, Anika, Mannion, Cynthia, Tough, Suzanne   +3 more
openaire   +1 more source