Results 61 to 70 of about 792,696 (271)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Race, Gender, Sexuality, and Religion in North America [PDF]

, 2017
The history of religion in the United States cannot be understood without attending to histories of race, gender, and sexuality. Since the 1960s, social and political movements for civil rights have ignited interest in the politics of identity ...
Petro, Anthony
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Revisiting the Sterilizations at Ravensbrück Concentration Camp: A Victim-Based History

Eastern European Holocaust Studies
Over decades of Holocaust scholarship, a similar narrative emerges on the sterilizations at Ravensbrück concentration camp: In January 1945, Professor Carl Clauberg experimentally sterilized between 120 and 140 Sinti and Roma women and girls in rapid ...
Maznick Tiarra
doaj   +1 more source

Wonders and Politics of the Chosŏn Dynasty: Reflections on the Unexplored Side of the Chosŏn Neo-Confucian System

Religions
Wonder was deeply rooted in the Chosŏn Neo-Confucian system. Through this wonder, we can see various layers of consciousness of Neo-Confucian scholars.
Jonghyun Na
doaj   +1 more source

Book Review: When Everything Changed: The Amazing Journey of American Women from 1960 to the Present

, 2012
Excerpt: This premise—that so much has changed, and that so much work still needs to be done— resides at the heart of Gail Collins’s excellent book, When Everything Changed: The Amazing Journey of American Women from 1960 to the Present.
Mock, Melanie Springer
core  

Re-establishing the ‘outsiders’: English press coverage of the 2015 FIFA Women’s World Cup [PDF]

, 2017
In 2015, the England Women’s national football team finished third at the Women’s World Cup in Canada. Alongside the establishment of the Women’s Super League in 2011, the success of the women’s team posed a striking contrast to the recent failures of ...
A goals fest?, Bassett shrugs off, Beth Fielding-Lloyd, Boyal S, Braden P, Chapman given big-game boost, Duemmler K, Dunning E, Elias N, Elias N, Elias N, Foucault M, Foucault M, Garside K, Godoy-Pressland A, Hope C, It is tactically naive, Jack Black, Johnson R, Kay O, Kidd D, Lawrence E, Leighton T, Leighton T, Leighton T, Leighton T, Leighton T, Liddle R, Lopez S, McVeigh T, Millard R, Moore G, Moore G, Moore G, Moore G, Newton K, Norman M, Northcroft J, Pfister G, Platell A, Reade B, Redknapp J, Samuel M, Scott A, Sheard K, Spiers G, Syed M, Taylor L, Taylor L, Taylor L, Taylor L, Taylor L, The future of football, This could become, Topping A, Velija P, Walters M, Walters M, Walters M, White J, Williams J, Williams J, Williamson DJ, Woodward K   +63 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

History of Key Events in Women’s Health Care

, 2016
In 1973, ninety-three percent of all American doctors were men (Ehrenreich and English). Gender based inequity permeates all spheres of women’s health care from employment to access to treatment to biologically-based myths of male superiority, yet women ...
Chambliss, Zoё M.
core  

Review essay: Disentangling feminisms from the cold war [PDF]

, 2020
Feminist thinkers have long argued for the centrality of sexuality, gender and women to the Cold War. They have critiqued the sexual language of ‘deep penetration’ and ‘orgasmic whumps’ used to describe nuclear arms race technology and argued that ...
Bellows-Blakely, Sarah
core   +1 more source