Results 201 to 210 of about 1,140,494 (284)
RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System
Advanced Science, EarlyView.Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic +21 morewiley +1 more sourceComputationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
Advanced Science, EarlyView.BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...Wenze Dingwiley +1 more sourceAsymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis
Advanced Science, EarlyView.Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang +7 morewiley +1 more sourceDual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins
Advanced Science, EarlyView.A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang +7 morewiley +1 more sourceReinforcement learning control of quantum error correction. [PDF]
NatureSivak V, Morvan A, Broughton M, Cortiñas RG, Bausch J, Senior AW, Neeley M, Eickbusch A, Shutty N, Beni LA, Spencer JS, Heras FJ, Edlich T, Abanin D, Abbas A, Acharya R, Aigeldinger G, Alcaraz R, Alcaraz S, Andersen TI, Ansmann M, Arute F, Arya K, Askew W, Astrakhantsev N, Atalaya J, Ballard B, Bardin JC, Bates H, Bengtsson A, Karimi MB, Bilmes A, Bilodeau S, Borjans F, Bourassa A, Bovaird J, Bowers D, Brill L, Brooks P, Browne DA, Buchea B, Buckley BB, Burger T, Burkett B, Bushnell N, Busnaina J, Cabrera A, Campero J, Chang HS, Chen S, Chiaro B, Chih LY, Cleland AY, Cochrane B, Cockrell M, Cogan J, Collins R, Conner P, Cook H, Courtney W, Crook AL, Curtin B, Damyanov M, Das S, Debroy DM, Demura S, Donohoe P, Drozdov I, Dunsworth A, Ehimhen V, Elbag AM, Ella L, Elzouka M, Enriquez D, Erickson C, Ferreira VS, Flores M, Burgos LF, Forati E, Ford J, Fowler AG, Foxen B, Fukami M, Fung AWL, Fuste L, Ganjam S, Garcia G, Garrick C, Gasca R, Gehring H, Geiger R, Genois É, Giang W, Gilboa D, Goeders JE, Gonzales EC, Gosula R, de Graaf SJ, Dau AG, Graumann D, Grebel J, Greene A, Gross JA, Guerrero J, Le Guevel L, Ha T, Habegger S, Hadick T, Hadjikhani A, Hamilton MC, Harrigan MP, Harrington SD, Hartshorn J, Heslin S, Heu P, Higgott O, Hiltermann R, Huang HY, Hucka M, Hudspeth C, Huff A, Huggins WJ, Jeffrey E, Jevons S, Jiang Z, Jin X, Joshi C, Juhas P, Kabel A, Kafri D, Kang H, Kang K, Karamlou AH, Kaufman R, Kechedzhi K, Khattar T, Khezri M, Kim S, Knaut CM, Kobrin B, Kostritsa F, Kreikebaum JM, Kudo R, Kueffler B, Kumar A, Kurilovich VD, Kutsko V, Lacroix N, Landhuis D, Lange-Dei T, Langley BW, Laptev P, Lau KM, Ledford J, Lee J, Lee K, Lester BJ, Leung W, Li L, Li WY, Li M, Lill AT, Livingston WP, Lloyd MT, Locharla A, De Lorenzo L, Lundahl D, Lunt A, Madhuk S, Maiti A, Maloney A, Mandrá S, Martin LS, Martin O, Mascot E, Das PM, Maslov D, Mathews M, Maxfield C, McClean JR, McEwen M, Meeks S, Miao KC, Minev ZK, Molavi R, Molina S, Montazeri S, Neill C, Newman M, Nguyen A, Nguyen M, Ni CH, Niu MY, Oas L, Orosco R, Ottosson K, Pagano A, Paolo AD, Peek S, Peterson D, Pizzuto A, Portoles E, Potter R, Pritchard O, Qian M, Quintana C, Ranadive A, Reagor MJ, Resnick R, Rhodes DM, Riley D, Roberts G, Rodriguez R, Ropes E, De Rose LB, Rosenberg E, Rosenfeld E, Rosenstock D, Rossi E, Roushan P, Rower DA, Salazar R, Sankaragomathi K, Sarihan MC, Satzinger KJ, Schaefer M, Schroeder S, Schurkus HF, Shahingohar A, Shearn MJ, Shorter A, Shvarts V, Small S, Smith WC, Sobel DA, Spells B, Springer S, Sterling G, Suchard J, Szasz A, Sztein A, Taylor M, Thiruraman JP, Thor D, Timucin D, Tomita E, Torres A, Torunbalci MM, Tran H, Vaishnav A, Vargas J, Vdovichev S, Vidal G, Heidweiller CV, Voorhees M, Waltman S, Waltz J, Wang SX, Ware B, Watson JD, Wei Y, Weidel T, White T, Wong K, Woo BWK, Wood CJ, Woodson M, Xing C, Yao ZJ, Yeh P, Ying B, Yoo J, Yosri N, Young E, Young G, Zalcman A, Zhang R, Zhang Y, Zhu N, Zobrist N, Zou Z, Babbush R, Bacon D, Boixo S, Chen Y, Chen Z, Devoret M, Hansen M, Hilton J, Jones C, Kelly J, Korotkov AN, Lucero E, Megrant A, Neven H, Oliver WD, Ramachandran G, Smelyanskiy V, Klimov PV. +298 moreeuropepmc +1 more source
