Results 41 to 50 of about 494,317 (213)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Kriz, Esneklik ve Yeni Normal: Pandemi Sonrası Türkiye’de Aile-İş Dengesi ve Örgütsel Uyum Süreçleri

Diyanet İlmi Dergi
Bu çalışma, Türkiye’de evden çalışmanın sosyo-demografik farklılıklarını ve toplumsal yansımalarını incelemek amacıyla ikincil verilere dayalı olarak gerçekleştirilmiştir.
Fatih Bıyıklı
doaj   +1 more source

L’incidence des pratiques de conciliation travail–famille dans les milieux de travail canadiens : les milieux syndiqués sont-ils mieux pourvus et la situation s’améliore-t-elle ?

Revue Interventions Économiques, 2010
Work-life and work-family issues have been high on the agenda over recent years. In this paper, we wanted to see if the situation had gotten better over recent years and analysed the Workplace and Employment Survey (WES) of Statistics Canada.
Elmustapha Najem, Diane-Gabrielle Tremblay   +1 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Balancing and Conflict Between Work and Family Life of Sandwiched Caregivers: A Scoping Review

Safety and Health at Work
The aim of this scoping review was to advance our understanding of the balancing and conflict between work and family life experienced by sandwiched caregivers.
Ayumi Honda, Mayo Ono, Takahiro Nishida, Sumihisa Honda   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Contrasting Conceptions of Work–Family Balance and the Implications for Satisfaction with Balance during the COVID-19 Pandemic

Social Sciences
Pandemic-related changes, including the expansion of remote work and the closure of schools and daycare supports, posed unprecedented challenges to parents’ conceptions of their work and home routines. Drawing on interviews with 88 heterosexual partnered
Sejin Um, Anne Kou, Carolyn E. Waldrep, Kathleen Gerson   +3 more
doaj   +1 more source