Results 51 to 60 of about 333,989 (256)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Relationship Between Work Engagement and Work-Family Enrichment: A Systematic Review and Meta-Analysis

Psychological Topics
The aim of this study is to systematically summarize and analyze the relationship between work engagement and work-family enrichment. The study focuses on two aspects: the empirical direction of the relationship and the examination of mediators and ...
Tadas Vadvilavičius, Aurelija Stelmokienė   +1 more
doaj   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Self-expansion of entrepreneurial women in the family interface

Człowiek i Społeczeństwo
Purpose: This study addresses the experiences of entrepreneurial women within the family interface, examining how gender roles influence their professional identity as self-expansion.
Michel Fickler
doaj   +1 more source

Positive Psychological Micro-Interventions to Improve the Work–Family Interface: Use Your Resources and Count Your Blessings

Frontiers in Psychology, 2020
The present study is designed to test the effectiveness of two positive psychological micro-interventions (“use your resources” and “count your blessings”) aimed at improving the combination of work and family roles.
Maria C. W. Peeters, Maria C. W. Peeters, Elianne F. van Steenbergen, Elianne F. van Steenbergen, Jan Fekke Ybema   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Online Work-Family Enrichment Self-Efficacy Program: A Pilot Randomized-Controlled Trial

Psychological Topics
This paper explores the effectiveness of a newly developed online self-paced training program for work-family enrichment self-efficacy in a Lithuanian employees sample.
Tadas Vadvilavičius, Aurelija Stelmokienė   +1 more
doaj   +2 more sources

Employees’ work–family enrichment in leadership context: systematic review and meta-analytical investigation

Business: Theory and Practice
The aim of this study is to systematically summarize and analyse the relationship between work-family enrichment/family-work enrichment and family-supportive supervisor behaviour. A systematic literature review procedure was applied to search and review
Tadas Vadvilavičius, Aurelija Stelmokienė   +1 more
doaj   +1 more source