Results 171 to 180 of about 25,491,123 (302)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.

UNLABELLED: Analysis of DNA methylation is a valuable tool to understand disease progression and is increasingly being used to create diagnostic and prognostic clinical biomarkers.
Sjöström, M, Ning, Y, Witte, ON, Boutros, PC, Huang, FW, Perry, MD, Gleave, M, Zwart, W, Shrestha, R, Phillips, T, Maher, CA, He, HH, Aggarwal, R, Fraser, M, Petricca, J, Small, EJ, Quigley, DA, Bjartell, A, Ye, W, Morgans, AK, Ashworth, A, Maurice-Dror, C, Ng, SWS, Moreno-Rodriguez, T, Haffner, MC, Levy, S, Beer, TM, Gilbert, LA, Zhao, SG, Fong, L, Rettig, MB, Annala, M, Bose, R, He, C, Lloyd, P, Mahajan, NP, Cui, X-L, McCarthy, E, Chou, J, Hua, JT, Evans, CP, Feng, FY, Li, H, Chen, S, Chen, WS, Foye, A, Zoubeidi, A, Chi, KN, Lang, JM, Bergamaschi, A, Chesner, L, Tran, PT, Lundberg, A, Herberts, C, Posadas, EM, Wyatt, AW, Luo, J, Maheshwari, A, Zhang, M, Thomas, GV, Huang, J, Reiter, RE, Alumkal, JJ, Lara, PN   +63 more
core   +1 more source

Patient frustration with time spent on advanced ovarian and metastatic breast cancer care. [PDF]

Gynecol Oncol Rep
Dona A, Boyle SJ, Jewett P, Huang Z, Parsons HM, Teoh D, Fan Y, Arend R, Henderson NL, Rocque G, Wolfson J, Blaes A, Vogel RI.   +12 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Barriers to survivorship care for adolescent and young adult cancer survivors: perspectives of survivors and cancer specialists. [PDF]

Front Oncol
Kojima Y, Ando Y, Nogami Y, Iwata S, Suzuki T, Satomi E.   +5 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

'Anything to Help Find a Cure' or 'It Doesn't Seem Worth It': an observational qualitative analysis using behaviour theory to understand motivation and barriers to observational cohort study participation. [PDF]

BMJ Open
JaKa MM, Henderson MSG, Fidler SJ, Gaudet MM, Ziegenfuss JY.   +4 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source