Results 71 to 80 of about 22,350,899 (207)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Job strain and health-related lifestyle: findings from an individual-participant meta-analysis of 118,000 working adults.

, 2013
We examined the associations of job strain, an indicator of work-related stress, with overall unhealthy and healthy lifestyles.Journal ArticleMeta-AnalysisResearch Support, Non-U.S.
Batty, G.D., Westerlund, Hugo,, Westerlund, H.,, Nyberg, Solja T, Clays, E., Ladwig, K. -H,, Clays, E.,, Nordin, Maria,, Nordin, M.,, Virtanen, M., Steptoe, A., Nyberg, S.T., Kittel, F., Marmot, Michael, Zins, M.,, Dragano, Nico, Lunau, T., Knutsson, Anders,, Erbel, R., Koskenvuo, Markku, Ferrie, Jane, Westerholm, Peter,, Oksanen, T.,, Clays, Els, Heikkilä, K.,, Ferrie, J. E.,, Oksanen, Tuula, Westerlund, Hugo, Pentti, J., Dragano, N., Casini, A.,, Batty, G. D.,, Kittel, France, Theorell, Töres, Virtanen, Marianna, Knutsson, Anders, Salo, Paula, Ladwig, K.-H., Fransson, E.I., Nordin, Maria, Marmot, M.G., De Bacquer, Dirk, Casini, Annalisa, Goldberg, M., Vahtera, J.,, Marmot, Michael G., Suominen, S.,, Casini, A., DeBacquer, Dirk, Batty, George David, Vahtera, Jussi, Nyberg, Solja T., Ladwig, Karl-Heinz, Westerholm, P.,, Fransson, E. I.,, Steptoe, A.,, Jöckel, K.-H., Fransson, Eleonor,, Fransson, Eleonor I, Fransson, Eleonor I,, Pentti, Jaana, Marmot, M. G.,, Singh-Manoux, A., IPD-Work Consortium, Erbel, R.,, Ferrie, Jane E, Pentti, J.,, Fransson, Eleonor I., Nyberg, Solja,, Westerholm, Peter, Knutsson, A., Marmot, Michael G, Heikkilä, Katriina, Batty, David, Heikkilä, Katriina,, Alfredsson, L.,, Vahtera, J., Koskenvuo, M.,, Batty, G David, Alfredsson, Lars, Ferrie, J.E., Nordin, M., Singh-Manoux, A.,, Zins, Marie, Ferrie, Jane E., Alfredsson, L., Singh-Manoux, Archana, Salo, P.,, Suominen, S., Dragano, N.,, Goldberg, Marcel, Kivimäki, Mika, Erbel, Raimund, Goldberg, M.,, Kivimaki, M., Kittel, F.,, Lunau, T.,, Jöckel, K. -H,, Westerlund, H., Oksanen, T., Nyberg, S. T.,, Suominen, Sakari, Westerholm, P.J., Kivimäki, M.,, Lunau, Thorsten, Heikkilä, K., Koskenvuo, M., DeBacquer, D.,, Steptoe, Andrew, Salo, P., Virtanen, M.,, Jöckel, Karl-Heinz, Batty, G. David, Zins, M., Debacquer, D., Suominen, S, Steptoe, A, Virtanen, M,, Fransson, EI, Heikkila, K, Nyberg, ST, Heikkilä, K;Fransson, EI;Nyberg, ST;Zins, M;Westerlund, H;Westerholm, P;Virtanen, M;Vahtera, J;Suominen, S;Steptoe, A;Salo, P;Pentti, J;Oksanen, T;Nordin, M;Marmot, MG;Lunau, T;Ladwig, KH;Koskenvuo, M;Knutsson, A;Kittel, F;Jöckel, KH;Goldberg, M;Erbel, R;Dragano, N;Debacquer, D;Clays, E;Casini, A;Alfredsson, L;Ferrie, JE;Singh-Manoux, A;Batty, GD;Kivimaki, M, Westerholm, P, Vahtera, J,, Zins, M, Westerlund, H,   +125 more
core   +1 more source

Beacons of Excellence in Stress Prevention [PDF]

, 2004
NoThis report describes the work of Robertson Cooper Ltd and UMIST to identify good practice in stress prevention and then identify organisations within the UK that could be called beacons of excellence in comparison to this model.
Gurr, E., Jordan, J., Faragher, B., Giga, Sabir I.   +3 more
core   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Stress Prevention@Work: a study protocol for the evaluation of a multifaceted integral stress prevention strategy to prevent employee stress in a healthcare organization: a cluster controlled trial

BMC Public Health, 2017
Background Adequate implementation of work-related stress management interventions can reduce or prevent work-related stress and sick leave in organizations.
Rianne J. A. Hoek, Bo M. Havermans, Irene L. D. Houtman, Evelien P. M. Brouwers, Yvonne F. Heerkens, Moniek C. Zijlstra-Vlasveld, Johannes R. Anema, Allard J. van der Beek, Cécile R. L. Boot   +8 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Organizational Change, Health and Sick Leave among Health Care Employees : A Longitudinal Study Measuring Stress Markers, Individual and Work Site Factors

, 2008
This controlled longitudinal study was conducted to investigate the effects of organizational change on employees' self-reported health, work satisfaction, work-related exhaustion, stress, and sick leave.
Hansson, Ann-Sophie,, Vingård, Eva,, Anderzén, Ingrid,, Arnetz, Bengt B,   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Emotion Regulation in Rescue Workers: Differential Relationship With Perceived Work-Related Stress and Stress-Related Symptoms

Frontiers in Psychology, 2019
Rescue workers are exposed to enduring emotional distress, as they are confronted with (potentially) traumatic mission events and chronic work-related stress.
Anne Gärtner, Alexander Behnke, Alexander Behnke, Daniela Conrad, Daniela Conrad, Iris-Tatjana Kolassa, Roberto Rojas   +6 more
doaj   +1 more source