Results 131 to 140 of about 9,913,320 (301)

Making the great transformation, November 13, 14, and 15, 2003 [PDF]

, 2003
This repository item contains a single issue of the Pardee Conference Series, a publication series that began publishing in 2006 by the Boston University Frederick S. Pardee Center for the Study of the Longer-Range Future.
Anderson, William P., Banuri, Tariq, Bard, Kathryn, Catanzaro, Frank, Clapp, Richard, Cleveland, Cutler, Conceição, Pedro, Costanza, Robert, Dewar, James, Fromkin, David, Fukuda-Parr, Sakiko, Gerring, John, Quadir, Iqbal, Raskin, Paul, Saundry, Peter, Starr, Douglas, Sue Wing, Ian, Thacker, Strom, Tracy, James, Woodcock, Curtis, Zakaria, Fareed, Zolli, Andrew   +21 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Study the relation between Work Ability Index and Life Style in Mechanics of Thermal power plant

Muhandisī-i bihdāsht-i ḥirfah/ī, 2016
Introduction: Maintenance of work ability and continuous effort to improve reduced work ability of employees is a major concern for managers. This study aimed to determine the level of work ability index and relation with life style in mechanics of ...
Keivan Saedpanah, Tahere Eskandary, Majid Moatamedzade, , ,   +5 more
doaj  

Did You Just Make That Up? Puns in Everyday Conversation [PDF]

, 2006
The hallmark of the compleat punster is the ability to work puns into real-life situations - and to do so in an appropriate, natural and spontaneous way.
Hauptman, Don
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A study on factors affecting on work ability among farmers in the Ashtian city

Salāmat-i kār-i Īrān, 2017
Background and aims: Monitoring workerschr('39') work ability, planning to maintain and improve the work ability, and identifying and controlling its related risk factors are of the most important issues in the field of occupational health. The object of
Akbar Rostam Abadi, Adel Mazloumi
doaj  

Long-term sickness absence trajectories and associated occupational and lifestyle-related factors: a longitudinal study among young and early midlife Finnish employees with pain

BMJ Open
Objectives This study aimed to identify distinct trajectories of long-term sickness absence (LTSA, >10 consecutive working days) among young and early midlife Finnish employees who experienced pain at baseline.
Karen Walker-Bone, Tea Lallukka, Ossi Rahkonen, Rahman Shiri, Pi Fagerlund   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analytical evaluation of work ability index and its determining factors among workers of a car manufacturing industry

Salāmat-i kār-i Īrān, 2012
Background and aims : The ability of work is the basis of well-being for all of us. Many factors affect the work ability such as work and work condition, work organization and human resource. The aim of this study was to assess the work ability among car
M Eyvazlou, A Mazloumi, A.A Farshad, F Hoseini   +3 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source