Results 121 to 130 of about 19,615,720 (298)

Effect on work ability after team evaluation of functioning regarding pain, self-rated disability, and work ability assessment

, 2010
Jan-Rickard Norrefalk1, Agneta Littwold-Pöljö2, Leif Ryhle3, Gunilla Brodda Jansen1,31Department of Clinical Sciences, Division of Rehabilitation Medicine, Karolinska Institutet, Stockholm, Sweden; 2Sophiahemmet Rehab Center, Stockholm,
Jan-Rickard Norrefalk, Norrefalk, J-R, Ryhle, L, Jansen, GB, et al, Gunilla Brodda Jansen, Leif Ryhle, Littwold-Poljo, A, Agneta Littwold-Pöljö   +8 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Work ability in patients with polymyositis and dermatomyositis: An explorative and descriptive study

, 2015
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are rare, chronic inflammatory diseases leading to muscle weakness and low muscle endurance. The muscle weakness may lead to restrictions in daily activities and low health-related quality of life ...
Welin Henriksson, Elisabet,, Lundberg, Ingrid E.,, Sandqvist, Jan,, Schult, Marie-Louise,, Regardt, Malin,, Sandqvist, J, Henriksson, EW, Schult, M-L, Lundberg, IE, Regardt, M,   +9 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Work ability and work quality as indicators for a longer and more productive working life.

, 2009
Objective: In order to cope with the new challenges posed by globalization, job tasks and mental and physical workloads have to be re-designed to fit with levels of productivity in an ageing workforce.
Meloni M, COCCO, PIER LUIGI, P. Cocco, G. Costa, Costa G., M. Meloni   +5 more
core   +1 more source

Physical and psychosocial prerequisites of functioning in relation to work ability and general subjective well-being among office workers

, 2002
Objectives The purpose of the study was to investigate the physical and psychological prerequisites of functioning, as well as the social environment at work and personal factors, in relation to work ability and general subjective well-being in a group ...
Mustalampi, Sirpa, Mälkiä, Esko, Leskinen, Esko, Markku T Ojanen, Sjögren-Rönkä, Tuulikki, Ojanen, Markku, Esko K Leskinen, Sirpa T Mustalampi, Tuulikki Sjögren-Rönkä, Esko A Mälkiä   +9 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Ohio ability (Online); Ability; Ohio ability magazine

, 2010
Four times a year.; Spring 2010-; "Jobs, independence and benefits for Ohioans with disabilities."; Offered in text-only (.doc), PDF, and audio (MP3) versions.; Harvested from the web on 1/27/11Each issue features articles about successful Ohioans who ...

core   +1 more source