Results 131 to 140 of about 3,783,867 (355)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Effort-Reward Imbalance and Work Ability Index among Italian female nurses : the role of family status

open access: yes, 2011
While research is mainly focused on the role of gender and biological/chronological age in the relationship between Work Ability Index and Effort/Reward Imbalance, this study addresses the association between work-related stress and work ability, taking
P. Campanini   +6 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Capacidade para o trabalho, saúde e ausência por doença de trabalhadoras de um centro de pesquisa por grupos de idade

open access: yesRevista Brasileira de Saúde Ocupacional
Este estudo avaliou a capacidade para o trabalho de trabalhadoras brasileiras por grupo de idade e ocupação e analisou as ausências por doença registradas durante um ano.
Maria Silvia Monteiro   +2 more
doaj   +1 more source

Effort Reward Imbalance and Work Ability among nurses and call-center operators

open access: yes, 2011
The aim of the study is to investigate the relationship between effort/reward imbalance and work ability in the nursing and call-center sectors. A selfreported questionnaire was completed by 1,113 nurses and 1,106 call-center operators.
G. Castellini   +5 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Associations between commute mode use and self-rated health and work ability among Finnish public sector employees

open access: hybrid, 2023
Essi Kalliolahti   +5 more
openalex   +1 more source

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