Results 101 to 110 of about 13,693,389 (293)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 1903 Contains papers read at the quarterly meetings of the society, and extracts from the discussions following them with other communications dealing with alcohol and alcoholism.Title varies slightly.Title from cover.None published July-Dec.
Society for the Study of Addiction to Alcohol and Other Drugs. +1 more
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Euphoria, Ecstacy, Inebriation, Abuse, Dependence, and Addiction: A Conceptual Analysis
, 2005 A conceptual analysis of basic notions of addictiology, i.e., Euphoria, Ecstasy, Inebriation, Abuse, Dependence, and Addiction was presented. Three different forms of dependence were distinguished: purely psychic, psycho-physiological, and purely somatic
Buhler, Karl-Ernst
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Addiction and Self-Control: An Intrapersonal Game [PDF]
In their model of addiction, O´Donoghue and Rabin obtain a counterintuitive result: a person that is fully aware of his self-control problems (sophisticate) is more prone to become addicted than one who is fully naware (na¨ıf).
López Rafael
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Validity evidence of the Dutch work addiction scale - Brazilian version [PDF]
, 2020 Workaholism is characterized by a state of mind in which professionals work excessively and compulsively. This study aimed to evaluate the psychometric properties of two versions of the Dutch Work Addiction Scale (DUWAS-16 and DUWAS-10) for the Brazilian
Schaufeli, Wilmar B. +6 more
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Addiction trends: Internet v casino gambling [PDF]
, 2006 Gambling addictions always result from an interaction and interplay between many factors including the person’s biological and/or genetic predisposition, their psychological constitution, their social environment and the nature of the activity itself ...
Griffiths, M
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The relationship between study addiction and work addiction: A cross-cultural longitudinal study [PDF]
, 2016 Aims Recent empirical studies investigating “study addiction” have conceptualized it as a behavioral addiction, defined within the framework of work addiction.
Ståle Pallesen +11 more
core +1 more source