Results 121 to 130 of about 13,693,389 (293)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Addiction to car use and dynamic elasticity measures in France [PDF]

This article presents a microeconometric analysis of the annual mileage travelled by French households with their personal cars, defining their automobility. To feature car use dependence, the rational addiction model of Becker et al.
Roger Collet, Mathieu De Lapparent, Laurent Hivert   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Online gaming and addiction: a psychosocial investigation using mixed methods [PDF]

, 2010
Online virtual worlds known as Massively Multiplayer Online Role-Playing Games (MMORPGs) have gained increased popularity over the last decade. MMORPGs provide a sophisticated environment that enables complete immersion within the virtual world to the ...
Hussain, Z
core  

‘Addiction is a hypothesis that a group of things we can observe have an underlying connection’. What is addiction, why does it develop, and how can it be treated?

, 2023
Professor Keith Humphreys tackles complicated questions in his 2023 book, “Addiction: a very short introduction”. This short, edited excerpt focuses on what scientists and medical professionals mean when they apply the word ‘addiction’ to humans.
Humphreys, Keith
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Addiction medicine: closing the gap between science and practice. [PDF]

, 2012
CASA Columbia’s new five year national study reveals that addiction treatment is largely disconnected from mainstream medical practice. While a wide range of evidence-based screening, intervention, treatment and disease management tools and practices ...

core  

Protocol for a new family history of addiction density score to aid in the treatment of alcohol and substance use disorders

Drug and Alcohol Dependence Reports
Background: While molecular and non-molecular genetic testing are the gold standard for assessing a person’s familial liability for substance use disorders, such testing is often inaccessible.
Jessica L. Bourdon, Jordan Wright, Sabrina Verdecanna, Mer W. Francis, Vivia V. McCutcheon   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Similarities and Differences Between Study Addiction and Study Engagement and Work Addiction and Work Engagement: A Network Analysis [PDF]

This study aimed to investigate the relationships between symptoms of study addiction and their relationships with dimensions of study engagement. We used two samples in which study addiction was measured with the Bergen Study Addiction Scale and study ...
Pallesen, Ståle, Bereznowski, Piotr, Atroszko, Paweł A., Konarski, Roman   +3 more
core   +1 more source