Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Barriers and solutions to addressing tobacco dependence in addiction treatment programs. [PDF]
, 2006 Despite the high prevalence of tobacco use among people with substance use disorders, tobacco dependence is often overlooked in addiction treatment programs.
Foulds, Jonathan +4 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Building a comprehensive understanding of 2SLGBTQ+ youth homelessness: a scoping review
International Journal for Equity in HealthTwo-spirit, lesbian, gay, bisexual, transgender, queer, questioning, plus additional sexual and gender diverse (2SLGBTQ+) youth are overrepresented among youth experiencing homelessness.
Alex Abramovich +5 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
COLLEGE STUDENT ALCOHOL USE: USING CURRENT RESEARCH TO GUIDE PRACTICE [PDF]
, 2009 Alcohol abuse has been described as the biggest health problem on college campuses today.This single statement illustrates the public health relevance of addressing college student alcohol use.
Guizzetti, Lisa M.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
İŞKOLİKLİK ÜZERİNE BİR ARAŞTIRMA
Sosyal Ekonomik Araştırmalar Dergisi, 2005 Popüler basında işkoliklik kavramına önemli ilgi gösterilmesine rağmen, işkolikliğin anlaşılması için çok az sayıda araştırma yapılmıştır. Bu çalışmada, ilk olarak işkoliklik ve işkoliklik ile ilgili araştırmalar incelenmektedir.
Ferit Ölçer
doaj +2 more sources
Personality traits and the degree of work addiction among Polish women: the mediating role of depressiveness. [PDF]
Front Public Health, 2023 Rachubińska K +6 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source