Results 111 to 120 of about 179,139 (288)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Drug and Alcohol Dependence ReportsBackground: While molecular and non-molecular genetic testing are the gold standard for assessing a person’s familial liability for substance use disorders, such testing is often inaccessible.
Jessica L. Bourdon +4 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Social Work with Addictions [PDF]
, 1995 The new edition of this important text has been fully revised and is an essential resource for those working in the field of drug addiction. Drug misuse tends to be encountered in the context of other, often more pressing social problems, such as child abuse, homelessness, domestic violence or emergency relief. This book responds to the needs
openaire +1 more source
Art therapy and addiction: Michelle Guinness talks to the SSA.
, 2020 Art Therapy in addiction is no longer solely hospital based. Today, Art Therapists work in a range of settings: within multidisciplinary teams, in community settings, schools, community centres and residential rehabs.
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Representing Addiction in Contemporary Media [PDF]
openThis thesis explores the multifaceted representations of addiction in various media with the aim of shedding light on the complex socio-cultural implications of these representations.
CHMIELARCZYK, MILENA
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Health ExpectationsBackground Although family inclusion is embraced in mental health policy and practice guidelines, families continue to report feeling devalued and/or excluded from service delivery.
Katherine Reid +4 more
doaj +1 more source