Results 71 to 80 of about 1,307,434 (301)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Is role clarity and workplace autonomy the key dilemma for multinational telecommunication organizations in developing countries?

Управленец
Role clarity and workplace autonomy are always considered a dilemma for employees to perform better to achieve their desired targets, which can affect organizational performance.
M.A. Zaheer, M.A. Raza, M. Manzoor, U.A. Raja   +3 more
doaj   +1 more source

Autonome comme si vous l’étiez

La Nouvelle Revue du Travail, 2014
One of digital machines’ main attributes is the way they split the meaning of sense (the attribution of finalities). This is a quantum leap from a past analogical phase where – through sensations and feedback effects – users could find themselves fully ...
Gérard Dubey
doaj   +1 more source

How Autonomy Can Legitimate Beneficial Coercion [PDF]

, 2017
Respect for autonomy and beneficence are frequently regarded as the two essential principles of medical ethics, and the potential for these two principles to come into conflict is often emphasised as a fundamental problem.
White, Lucie
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Examining the associations between mental health, life balance, work-method autonomy, and perceived boundary control among postdoctoral fellows

Frontiers in Psychology
High mental health risks and life imbalance among postdoctoral fellows (postdocs) are persistent concerns in academia. However, little is known about the relationship between these two subjects and whether autonomy at work is linked to life balance among
Brian K. Lo, In Young Park, David Choung, Melissa McTernan, Erin Sibley, Kirsten K. Davison   +5 more
doaj   +1 more source

Le « syndicalisme de base » dans l’Argentine kirchneriste. Une autonomie en question

Cahiers des Amériques Latines, 2017
In the course of last ten years, the dynamism of the trade union Argentine movement was obtained from, on the one hand, the reaffirmation of the political roll of the trade union directions and the increase of the collective bargaining and, on the other ...
Santiago Duhalde, Juan S. Montes Cató, Pierre Rouxel   +2 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

The double-edged sword effect of illegitimate tasks on hotel industry employees’ self-control behavior

Frontiers in Psychology
IntroductionIllegitimate tasks are a significant workplace stressor in the hotel industry, yet their impact on employees’ self-control behavior remains inconclusive, with prior studies reporting both negative and positive effects.MethodsDrawing on ...
Wenjing Ke, Bingjie Sun
doaj   +1 more source