Results 61 to 70 of about 1,307,434 (301)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Is Autonomy Always Beneficial for Work Engagement? A Six-year Four-Wave Follow-Up Study

open access: yesJournal for Person-Oriented Research, 2020
Work engagement is expected to result from job resources such as autonomy. However, previous results have yielded that the autonomy–work engagement relationship is not always particularly strong.
Piia Seppälä   +4 more
doaj   +1 more source

Au service du public. Le « bon travail » ouvrier dans la restauration du CROUS

open access: yesLa Nouvelle Revue du Travail, 2023
Based on a direct observation survey and interviews with catering workers at a CROUS (Regional Center for University and School Works), this article shows how they come to deploy collective strategies so that their work can be carried out under good ...
Ludivine Balland   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Evidence-based medicine and values-based medicine : partners in clinical education as well as in clinical practice [PDF]

open access: yes, 2013
The best clinical decisions are based on both evidence and values in what is known as the ‘twofeet principle’. Anecdotally, educationalists find teaching clinicians to become more evidence based is relatively simple in comparison to encouraging them to ...
DL Sackett   +8 more
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A little less autonomy? The future of working time flexibility and its limits [PDF]

open access: yes, 2020
The European Court of Justice has recently issued rulings on the interpretation of the European Working Time Directive 2003/88, which appear to restrict flexible working time arrangements(especially Matzak C-518/15,Syndicat C-254/18 and CCOOC-55/18 ...
Glowacka, Marta Joanna
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Employee innovation in the context of strategic change implementation in the service sector

open access: yesMенаџмент у хотелијерству и туризму
Purpose – The purpose of this paper is to determine whether variables – managerial support for innovative ideas, work autonomy, rewards/reinforcements, time availability, organizational barriers, and specific parameters of organizational climate, have ...
Jelena Erić Nielsen   +2 more
doaj   +1 more source

Factors Associated with Preferences Regarding Selected Forms of Variable Pay: A Replication and Extension [PDF]

open access: yes, 2013
This study investigates the relationships among being paid via different variable pay systems, perceptions regarding selected work environment characteristics, and preferences regarding selected variable pay plans.
Inderrieden, Edward   +2 more
core   +1 more source

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