Results 71 to 80 of about 2,558,450 (356)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The New Male Mystique [PDF]

, 2011
Examines the rise in men reporting work-family conflict, factors that put men at risk for conflict, and those that help reduce it, including supervisor support and workplace flexibility.
Ellen Galinsky, Kenneth Matos, Kerstin Aumann   +2 more
core  

Role resources and work-family enrichment: The role of work engagement [PDF]

, 2010
The majority of work-family research has focused on negative spillover between demands and outcomes and between the work and family domains (e.g., work-family conflict; see review by Eby, Casper, Lockwood, Bordeaux, & Brinley, 2005).
Bakker, Arnold B., Brough, Paula, Chen, Wei-qing, Kalliath, Thomas, Lo, Danny, Lu, Chang-Qin, Lu, Jia-fang, O’Driscoll, Michael P., Phillips, David R., Shi, Kan, Sit, Cindy, Siu, Oi Ling   +11 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Work-Family Conflict Impact on Psychological Safety and Psychological Well-Being: A Job Performance Model

Frontiers in Psychology, 2020
In a modern working environment characterized by new technology and work assignments extended to personal time, employees are expected to balance multiple roles while maintaining maximum productivity.
Bojan Obrenovic, Du Jianguo, Akmal Khudaykulov, Muhammad Aamir Shafique Khan   +3 more
doaj   +1 more source

Pengaruh Work-family Conflict dan Stres Kerja terhadap Kepuasan Kerja dan Turnover Intention Karyawan Wanita [PDF]

, 2016
Penelitian ini bertujuan untuk mengetahui pengaruh work-family conflict dan stres kerja terhadap kepuasan kerja dan turnover intention karyawan wanita pada Bank Rakyat Indonesia (BRI) Kantor Cabang Gatot Subroto Denpasar.
Rahyuda, A. G. (Agoes), Sudibya, I. G. (I), Yani, N. W. (Ni)   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Pengaruh Konflik Pekerjaan dan Konflik Keluarga Terhadap Kinerja dengan Konflik Pekerjaan Keluarga Sebagai Intervening Variabel (Studi pada Dual Career Couple di Jabodetabek)

Jurnal Manajemen dan Wirausaha, 2010
The purpose of this research is finding how the influence of working conflict towards family conflict, the influence of working conflict to working family conflict, the influence of family conflict to working family conflict and the influence of working ...
Christine W.S., Megawati Oktorina, Indah Mula   +2 more
doaj  

The Effect of Work-Family Conflict and Family-Work Conflict on Individual Job Performance in Nurses

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: This study was conducted to determine the effect of work-family and family-work conflict levels of nurses on their individual job performance. Method: The sample of this descriptive and correlational design study consisted of 305 nurses.
Fatmanur Karaman, Ülkü Baykal, Seyhan Çerçi   +2 more
doaj   +1 more source