Results 81 to 90 of about 959,345 (306)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting

Frontiers in Psychology
IntroductionWhile the impact of work–family conflict (WFC) and family–work conflict (FWC) on employee well-being is well documented, less is known about how burnout may, in turn, increase these conflicts through diminished self-regulatory capacity in a ...
Jesus Yeves, Jesus Yeves, Laura Trujillo, Mariana Bargsted, Mariana Bargsted, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega, Andy Luis Marrero-Vega   +7 more
doaj   +1 more source

Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface

Frontiers in Psychology, 2016
Background: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities ...
Anna Maria Dåderman, Beata Aleksandra Basinska, Beata Aleksandra Basinska   +2 more
doaj   +1 more source

Work and Family Interface: Wellbeing and the Role of Resilience and Work-Life Balance

, 2012
Wellbeing research has recently gathered impetus largely due to the emergence of positive psychology. Researchers and practitioners are now exploring the science of positive subjective experiences, positive traits, positive states, aspects of human ...
Riley, Derek
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Pengaruh Dukungan Supervisor Terhadap Work Family Conflict

Wacana: Jurnal Sosial dan Humaniora, 2016
Penelitian empiris di bidang work family conflict (konflik antara kerja dan keluarga) menunjukkan bahwa work family conflict memiliki dampak yang negatif terhadap individu, keluarga dan organisasi.
Wike Wike, Endah Setyowati, Tri Wulida Afrianty, Tulus Sabrina   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Work-Family Conflict & Family-Work Conflict: A Gender Perspective with Impact on Life Satisfaction

, 2022
Nowadays most employed adults are found to be struggling with the work and family conflict which adversely impact their life-satisfaction, thus, the current study aims to bring forth the gender differences in work-family conflict (WFC) and family-work conflict (FWC) and their impact on the life satisfaction of the employed adults.
openaire   +2 more sources

Crossover specificity of team-level work-family conflict to individual-level work-family conflict

, 2009
Purpose – this study aims to investigate the crossover specificity of team-level stressors to individual-level work-family conflict.design/methodology/approach – the paper takes the form of a multilevel analyses with data from 428 employees of a dutch ...
Work and Organizational Psychology: Occupational Health Psychology, Van Emmerik, IJ.H., Afd Sociale-,gezondheids- en organ.psych, van Emmerik, I.H., Peeters, M.C.W.   +4 more
core   +1 more source