Results 81 to 90 of about 2,558,450 (356)

Anteseden Konflik Pekerjaan-keluarga dan Pengaruhnya terhadap Tingkat Kehadiran di Tempat Kerja (Studi Kasus Uptd Pendidikan Kecamatan Sagulung Kota Batam) [PDF]

open access: yes, 2017
The purpose of this study is to obtain empirical evidence about the influence of Antecedents Work Family Conflict on the Level of Attendance at Work (Case Study UPTD Sagulung District of Batam). The population of this study is 130 female teachers in UPTD
UPB, J. I. (Jurnal)
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface

open access: yesFrontiers in Psychology, 2016
Background: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities ...
Anna Maria Dåderman   +2 more
doaj   +1 more source

Work-Family Conflict and Working Conditions in Western Europe

open access: yesSocial Indicators Research, 2009
This article explores the influence of working conditions on work-family conflict (WFC) among married/cohabiting employees across seven European countries. Using data from the European Social Survey, the paper first investigates the role of working conditions relative to household level characteristics in mediating work-family conflict at the ...
Gallie, D, Russell, H
openaire   +3 more sources

Direct and indirect effects of work-family conflict on job performance [PDF]

open access: yes, 2008
A model is developed on the effects of work-family conflict on employees’ emotional exhaustion, job satisfaction and job performance based on the role theory and the conservation of resources theory as well as related studies.
Ahmad, Aminah
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Burnout and inter-role conflict in telework: a gendered resource erosion pathway via job crafting

open access: yesFrontiers in Psychology
IntroductionWhile the impact of work–family conflict (WFC) and family–work conflict (FWC) on employee well-being is well documented, less is known about how burnout may, in turn, increase these conflicts through diminished self-regulatory capacity in a ...
Jesus Yeves   +7 more
doaj   +1 more source

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