Results 101 to 110 of about 554,369 (294)

The X-ray Cluster Normalization of the Matter Power Spectrum

, 2008
The number density of galaxy clusters provides tight statistical constraints on the matter fluctuation power spectrum normalization, traditionally phrased in terms of sigma_8, the root mean square mass fluctuation in spheres with radius 8 h^-1 Mpc.
Albrecht, Andisheh Mahdavi, Arif Babul, August E. Evrard, Dahle, de Vaucouleurs, Dunkley, Eisenstein, Evrard, Evrard, Girardi, Gladders, Henk Hoekstra, Henry, Henry, Horner, Hu, J. Patrick Henry, Jarvis, Kaiser, Komatsu, Kravtsov, Levine, Lupton, Maughan, Nagai, Nagai, Navarro, Nord, Novicki, Peacock, Rasia, Reiprich, Rines, Rines, Rines, Rozo, Spergel, Spergel, Stanek, Sun, Tinker, Vikhlinin, Vikhlinin, Voevodkin, Warren, Łokas   +46 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Entropy, non-ergodicity and non-Gaussian behaviour in ballistic transport

, 2007
Ballistic transportation introduces new challenges in the thermodynamic properties of a gas of particles. For example, violation of mixing, ergodicity and of the fluctuation-dissipation theorem may occur, since all these processes are connected.
Aitken A. C., Astumian R. D., Budini A. A., Costa I. V. L., F. A Oliveira, Huang K., I. V. L Costa, Kubo R., Kubo R., L. C Lapas, Lee M. H., M. H Vainstein, Metzler R., Oshanin G., Reguera D., Vainstein M. H.   +15 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Mathematical Modeling of Transient Submerged Entry Nozzle Clogging and Its Effect on Flow Field, Bubble Distribution and Interface Fluctuation in Slab Continuous Casting Mold

Metals
Submerged entry nozzle (SEN) clogging will affect the production efficiency and product quality in the continuous casting process. In this work, the transient SEN clogging model is developed by coupling the porous media model defined by the user-defined ...
Yuntong Li, Wenyuan He, Changliang Zhao, Jianqiu Liu, Zeyu Yang, Yuhang Zhao, Jian Yang   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Research on the optimization of grouting flow detection sensor layouts based on laser ranging technology

Scientific Reports
Accurate grouting flow measurement is critical for optimizing construction quality and reducing material waste in geotechnical engineering. While electromagnetic flowmeters are widely used, their precision deteriorates significantly under low-flow ...
Lichang Wang, Wei Long, Zhanghui Fei, Zhongli Yang, Meng Xu, Lu Wang   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source