Results 71 to 80 of about 44,103 (262)
Materials Science & Engineering: A, 2018 Al0.3CoCrFeNi is an FCC-based high entropy alloy (HEA) that can display a wide spectrum of mechanical properties. Cold work and precipitation are good strengthening mechanisms in this HEA, and their effect on dynamic work hardening and strain rate ...
S. Gangireddy +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Work-Hardening in Three-Dimensional Slip-Line Fields
Engineering Transactions, 1996 A slip-line field theory that includes rotational continuity, published in an earlier article and shown therein to lead to Hill's equiangular net, is extended to include work-hardening.
R.L. Bish
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2017 To improve the mechanical properties of additively manufactured parts, specific heat treatments must be developed. Annealing of electron beam-melted Ti–6Al–4V was performed at sub-transus temperatures and followed by water quenching.
Charlotte de Formanoir +8 more
semanticscholar +1 more source
MedžiagotyraThe thermo-stability of microstructure during isothermal annealing at 900 °C and 1000 °C in a cold-worked Cu-Al2O3 composite with 0.1 wt.% Al content and its effect on resistance to softening were investigated in this paper.
Dongping ZHANG +4 more
doaj +1 more source
Hot deformation behaviors and microstructure evolution of Mg–Si–Sr alloy
Materials Research Express, 2020 The hot deformation behavior and microstructural evolution of as-extruded Mg-0.55 wt.%Si-0.75 wt.%Sr alloys at 250 °C with the compressive strain rate of 1 s ^−1 , 0.1 s ^−1 , 0.01 s ^−1 and 0.001 s ^−1 were investigated via electron backscatter ...
Lei Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source