Results 91 to 100 of about 243,937 (306)

Effects of the Unified Viscoplastic Formulation and Temperature Terms on the Thermomechanical Behavior of Soldering Materials [PDF]

, 2012
Solder materials are critical packaging compounds and due to usually weakest melting temperature among packaging constitutive materials, thus, they are frequently subjected to a multitude of physical phenomena: creep, fatigue and combined hardening ...
Alexis, Joël, Dalverny, Olivier, Karama, Moussa, Msolli, Sabeur   +3 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Nanoparticle-induced Zener Pinning Effect on Strain-softening in a Cold-Worked Cu-Al2O3 Composite with 0.1 wt.% Al Content

Medžiagotyra
The thermo-stability of microstructure during isothermal annealing at 900 °C and 1000 °C in a cold-worked Cu-Al2O3 composite with 0.1 wt.% Al content and its effect on resistance to softening were investigated in this paper.
Dongping ZHANG, Peng WEI, Hengju LI, Zhihui CHEN, Kuixian WEI   +4 more
doaj   +1 more source

Why is Understanding Glassy Polymer Mechanics So Difficult?

, 2011
In this Perspective, I describe recent work on systems in which the traditional distinctions between (i) unentangled vs. well-entangled systems and (ii) melts vs. glasses seem least useful, and argue for the broader use in glassy polymer mechanics of two
Angell, Arruda, Baljon, Boyce, Capaldi, Chen, Chen, Chen, Chen, de Focatiis, Doi, Dupaix, Ediger, Everaers, Fetters, Foffi, Govaert, Govaert, Graessley, Haward, Haward, Hoy, Hoy, Hoy, Hoy, Hoy, Koga, Kramer, Kremer, Lee, Lee, Loo, Mattson, McGraw, McLeish, O'Hern, Plimpton, Riggleman, Senden, Stillinger, Tkachenko, Ube, Uchidaa, van Melick, Varghese, Warren, Ylitalo   +46 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Closed form solution of the return mapping algorithm in elastoplasticity [PDF]

, 2017
In the present work a return mapping algorithm is discussed for small strain elastoplasticity boundary value problems with an exact closed form solution of the local constitutive equations.
De Angelis, Fabio, Taylor, Robert L.
core  

A viscoplasticity model with an enhanced control of the yield surface distortion

, 2012
A new model of metal viscoplasticity, which takes combined isotropic, kinematic, and distortional hardening into account, is presented. The basic modeling assumptions are illustrated using a new two-dimensional rheological analogy.
Ihlemann, J., Shutov, A. V.
core   +1 more source

Revisiting the thermodynamics of hardening plasticity for unsaturated soils [PDF]

, 2010
A thermodynamically consistent extension of the constitutive equations of saturated soils to unsaturated conditions is often worked out through the use a unique 'effective' interstitial pressure, accounting equivalently for the pressures of the ...
Alonso, Bear, Bear, Bishop, Bishop, Bolzon, Chateau, Collins, Coussy, Coussy, Coussy, Coussy, Coussy, Coussy, Cui, de Gennes, Fredlund, Gallipoli, Gens, Gray, Halphen, Hassanizadeh, Houlsby, Houlsby, Hutter, Jean Vaunat, Jean-Michel Pereira, Jennings, Khalili, Lemaitre, Lewis, Lewis, Li, Loret, Luong, Matyas, Murad, Olivier Coussy, Pereira, Roscoe, Roscoe, Schofield, Sheng, Sun, Sun, Vaunat, Wheeler, Wheeler   +47 more
core   +5 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Thermo-mechanical FE model with memory effect for 304L austenitic stainless steel presenting microstructure gradient [PDF]

, 2012
The main purpose of this study is to determine, via a three dimensions Finite Element analysis (FE), the stress and strain fields at the inner surface of a tubular specimen submitted to thermo-mechanical fatigue.
Bompard, Philippe, Clavel, Michel, Curtit, Francois, Pécheur, Anne Le, Rey, Colette, Stephan, Jean-Michel   +5 more
core   +6 more sources