Results 91 to 100 of about 44,103 (262)

Controlling the work hardening of martensite to increase the strength/ductility balance in quenched and partitioned steels

open access: yes, 2017
The role of retained austenite on tensile behavior in quenched and partitioned (Q&P) steels has been studied extensively, but the deformation behavior of martensite, which comprises the majority of Q&P microstructures, has received less attention.
K. Findley   +3 more
semanticscholar   +1 more source

Enhancing the Mechanical Properties of a Hot Rolled High-Strength Steel Produced by Ultra-Fast Cooling and Q&P Process

open access: yesMetals, 2019
The quenching and partitioning (Q&P) process of advanced high strength steels results in a significant enhancement in their strength and ductility.
Teng Wu   +4 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Effects of SiCp distribution on microstructure, mechanical properties and deformation behavior of SiCp/2024Al composites

open access: yesCailiao gongcheng
SiCp/2024Al composite was prepared by semi-solid stirring casting, and the distribution of SiCp was regulated by multi-step deformation of hot extrusion and multi-direction forging (MDF).
XUE Pengpeng   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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