Results 111 to 120 of about 243,937 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of SiCp distribution on microstructure, mechanical properties and deformation behavior of SiCp/2024Al composites

Cailiao gongcheng
SiCp/2024Al composite was prepared by semi-solid stirring casting, and the distribution of SiCp was regulated by multi-step deformation of hot extrusion and multi-direction forging (MDF).
XUE Pengpeng, DENG Kunkun, NIE Kaibo, SHI Quanxin, LIU Li   +4 more
doaj   +1 more source

Simulation of Work Hardening in Machining Inconel 718 with Multiscale Grain Size. [PDF]

Materials (Basel), 2023
Zhuang K, Wang Z, Zou L, Fu C, Weng J.
europepmc   +1 more source

On Computational Modelling of Strain-Hardening Material Dynamics [PDF]

, 2012
In this paper we show that entropy can be used within a functional for the stress relaxation time of solid materials to parametrise finite viscoplastic strain-hardening deformations.
Barton, Philip, Romenski, Evgeniy
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Effect of Annealing Temperature on Mechanical Properties and Work Hardening of Nickel-Saving Stainless Steel. [PDF]

Materials (Basel), 2023
Pei W, Yang S, Cao K, Zhao A.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effect of Austempering Processes on the Tensile Properties and the Work-Hardening Behavior of Austempered Bainitic Steels Below the Martensite Start Temperature. [PDF]

Materials (Basel), 2023
Wang K, Hu F, Zhou W, Yershov S, Li L, Wu K.   +5 more
europepmc   +1 more source

A novel indicator for kinematic hardening effect quantification in deep drawing simulation [PDF]

, 2019
Deep drawing simulation techniques reduce tool design costs and improve tool performance and reliability. In terms of strain hardening, mixed models capturing the kinematic effect are sometimes more accurate than isotropic models.
Brosius, Alexander, Küsters, Niklas, Lafarge, Rémi   +2 more
core