Results 101 to 110 of about 13,124,768 (302)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Metodologias de investigação para metais utilizados em conformação plástica [PDF]
, 2007 Doutoramento em Engenharia MecânicaNeste trabalho apresentam-se novas metodologias experimentais de análise dos mecanismos físicos que controlam a formabilidade das ligas de Al-Mg e o encruamento transitório em metais unifásicos. Para as ligas de Al-Mg a
Vincze, Gabriela Tamara
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Work-hardening of Foil Crystals of Copper [PDF]
, 2010 application/pdfAn investigation has been made on the plastic properties of recrystallized copper foil crystals of which thicknesses are down to 6.6 microns.
SUMINO, Koji, YAMAMOTO, Mikio
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Cailiao gongchengSiCp/2024Al composite was prepared by semi-solid stirring casting, and the distribution of SiCp was regulated by multi-step deformation of hot extrusion and multi-direction forging (MDF).
XUE Pengpeng +4 more
doaj +1 more source
Structure and Mechanical Properties of AlMg4.5 And AlMg4.5Mn Wires Extruded by Kobo Method
Archives of Metallurgy and Materials, 2014 W pracy badano wpływ liczby operacji wyciskania metodą KoBo (z identycznym sumarycznym stopniem przerobu λ = 100) na strukturę, własności mechaniczne i charakterystyki umocnieniowe drutów ze stopów AlMg4.5 i AlMg4.5Mn (AA5083). Stwierdzono, że wyciskanie
Jaskowski M., Pieła K., Błaz L.
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The Surface Integrity of Titanium Alloy When Using Micro-Textured Ball-End Milling Cutters
Micromachines, 2018 Processing certain kinds of micro-textures onto the surface of tools can improve their wear resistance, reduce the friction between them and machined surfaces, prolong their service life and improve their processing efficiency.
Shucai Yang, Song Yu, Chunsheng He
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Work hardening correlation for monotonic loading based on state variables [PDF]
, 1977 An absolute work hardening correlation in terms of the hardness parameter and the internal stress based on the state variable approach was developed. It was found applicable to a variety of metals and alloys.
Huang, F. H., Li, C. Y.
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