Results 81 to 90 of about 44,103 (262)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Constitutive modeling of deformation behavior of high-entropy alloys with face-centered cubic crystal structure

Materials Research Letters, 2017
A constitutive model based on the dislocation glide and deformation twinning is adapted to face-centered cubic high-entropy alloys (HEAs) as exemplified by the CrMnFeCoNi system.
Min Ji Jang, Dong-Hyun Ahn, Jongun Moon, Jae Wung Bae, Dami Yim, Jien-Wei Yeh, Yuri Estrin, Hyoung Seop Kim   +7 more
doaj   +1 more source

Composition―Nanostructure Steered Performance Predictions in Steel Wires

Nanomaterials, 2019
Neutron scattering in combination with scanning electron and atomic force microscopy were employed to quantitatively resolve elemental composition, nano- through meso- to metallurgical structures and surface characteristics of two commercial stainless ...
Kun V. Tian, Francesca Passaretti, Adelaide Nespoli, Ernesto Placidi, Roberta Condò, Carla Andreani, Silvia Licoccia, Gregory A. Chass, Roberto Senesi, Paola Cozza   +9 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastable austenite driven work-hardening behaviour in a TRIP-assisted dual phase steel

, 2017
The mechanically-induced transformation behaviour of the metastable austenite phase in a high-strength industrial TRIP-assisted Dual Phase steel was monitored in situ using high-energy synchrotron diffraction under uniaxial loading.
B. Ennis, E. Jimenez-Melero, E. Atzema, M. Krugla, M. Azeem, D. Rowley, D. Daisenberger, D. Hanlon, P. Lee   +8 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Deformation mechanisms and work-hardening behavior of transformation-induced plasticity high entropy alloys by in -situ neutron diffraction

Materials Research Letters, 2018
A full picture of tensile deformation mechanism evolution in the FCC-to-HCP transformation-induced plasticity high entropy alloy (TRIP-HEA) was revealed by real-time in situ neutron diffraction. Three transition points, i.e. the triggering of TRIP in the
S. Fu, H. Bei, Y. Chen, T. Liu, D. Yu, K. An   +5 more
semanticscholar   +1 more source

Development of Bake Hardening Effect by Plastic Deformation and Annealing Conditions [PDF]

Metalurgija, 2006
The paper deals with the classification of steel sheets for automotives industry on the basis of strength and structural characteristics. Experimental works were aimed to obtain the best possible strengthening parameters as well as work hardening and ...
Kvačkaj, T., Mamuzić, I.
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source